التفاصيل البيبلوغرافية
| العنوان: |
Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. |
| المؤلفون: |
Matsuura, Katsuhisa1,2 mkatu2002@yahoo.co.jp, Honda, Atsushi1, Nagai, Toshio3, Fukushima, Noritoshi1, Iwanaga, Koji3, Tokunaga, Masakuni3, Shimizu, Tatsuya2, Okano, Teruo2, Kasanuki, Hiroshi1, Hagiwara, Nobuhisa1, Komuro, Issei3 komuro-tky@umin.ac.jp |
| المصدر: |
Journal of Clinical Investigation. Aug2009, Vol. 119 Issue 8, p2204-2217. 14p. 1 Black and White Photograph, 2 Charts, 7 Graphs. |
| مصطلحات موضوعية: |
*CELLULAR therapy, *TRANSPLANTATION of organs, tissues, etc., *HEART failure treatment, *MYOCARDIAL infarction, *STEM cells, *HEART cells, *CYTOKINES, *OXIDATIVE stress, *STEM cell transplantation, *MYOCARDIAL infarction treatment, *ANTIGEN analysis, *CELL differentiation, *RESEARCH, *CELL culture, *ANIMAL experimentation, *RESEARCH methodology, *CELL physiology, *CELL receptors, *MEDICAL cooperation, *EVALUATION research, *CELL motility, *RATS, *COMPARATIVE studies, *CELLS, *VASCULAR endothelial growth factors, *MICE, *ANTIGENS |
| مستخلص: |
Cardiac progenitor cells are a potential source of cell therapy for heart failure. Although recent studies have shown that transplantation of cardiac stem/progenitor cells improves function of infarcted hearts, the precise mechanisms of the improvement in function remain poorly understood. The present study demonstrates that transplantation of sheets of clonally expanded stem cell antigen 1-positive (Sca-1-positive) cells (CPCs) ameliorates cardiac dysfunction after myocardial infarction in mice. CPC efficiently differentiated into cardiomyocytes and secreted various cytokines, including soluble VCAM-1 (sVCAM-1). Secreted sVCAM-1 induced migration of endothelial cells and CPCs and prevented cardiomyocyte death from oxidative stress through activation of Akt, ERK, and p38 MAPK. Treatment with antibodies specific for very late antigen-4 (VLA-4), a receptor of sVCAM-1, abolished the effects of CPC-derived conditioned medium on cardiomyocytes and CPCs in vitro and inhibited angiogenesis, CPC migration, and survival in vivo, which led to attenuation of improved cardiac function following transplantation of CPC sheets. These results suggest that CPC transplantation improves cardiac function after myocardial infarction through cardiomyocyte differentiation and paracrine mechanisms mediated via the sVCAM-1/VLA-4 signaling pathway. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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