Targeted Destruction of DNA Replication Protein Cdc6 by Cell Death Pathways in Mammals and Yeast
| العنوان: | Targeted Destruction of DNA Replication Protein Cdc6 by Cell Death Pathways in Mammals and Yeast |
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| المؤلفون: | Heinz Baumann, Karuna Sharma, William C. Burhans, Xiaolei Sun, Frédéric Blanchard, Crisanto Gutierrez, M. Mar Castellano, Ivan Todorov, Michael E. Rusiniak |
| المصدر: | Molecular Biology of the Cell. 13:1536-1549 |
| بيانات النشر: | American Society for Cell Biology (ASCB), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | DNA Replication, DNA re-replication, Proteasome Endopeptidase Complex, Indoles, Saccharomyces cerevisiae Proteins, Cyclohexanecarboxylic Acids, Ultraviolet Rays, Apoptosis, Cell Cycle Proteins, Eukaryotic DNA replication, Saccharomyces cerevisiae, Pre-replication complex, Article, Cell Line, DNA replication factor CDT1, Duocarmycins, Control of chromosome duplication, Multienzyme Complexes, Cyclohexenes, Humans, DNA, Fungal, Molecular Biology, S phase, Benzofurans, biology, Caspase 3, Tumor Necrosis Factor-alpha, Ubiquitin, Nuclear Proteins, Cell Biology, Fibroblasts, Cell biology, Cysteine Endopeptidases, Adozelesin, Caspases, biology.protein, Origin recognition complex, DNA Damage |
| الوصف: | The highly conserved Cdc6 protein is required for initiation of eukaryotic DNA replication and, in yeast and Xenopus, for the coupling of DNA replication to mitosis. Herein, we show that human Cdc6 is rapidly destroyed by a p53-independent, proteasome-, and ubiquitin-dependent pathway during early stages of programmed cell death induced by the DNA-damaging drug adozelesin, or by a separate caspase-dependent pathway in cells undergoing apoptosis through an extrinsic pathway induced by tumor necrosis factor-α and cycloheximide. The proteasome-dependent pathway induced by adozelesin is conserved in the budding yeast Saccharomyces cerevisiae. The destruction of Cdc6 may be a primordial programmed death response that uncouples DNA replication from the cell division cycle, which is reinforced in metazoans by the evolution of caspases and p53. |
| تدمد: | 1939-4586 1059-1524 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fde60a68a35a89f798981b96fa7fbaTest https://doi.org/10.1091/mbc.02-02-0010Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a3fde60a68a35a89f798981b96fa7fba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19394586 10591524 |
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