المؤلفون: Terrence Town, Tomotaka Yokoo, Takashi Mori, Masahiro Maeda, Jun Tan, Naoki Koyama, Darrell Sawmiller, Tatsuya Segawa

المصدر: J Biol Chem

مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, ADAM10, Mice, Transgenic, medicine.disease_cause, Biochemistry, Presenilin, 03 medical and health sciences, ADAM10 Protein, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, Gallic Acid, mental disorders, medicine, Presenilin-1, Animals, Aspartic Acid Endopeptidases, Humans, Molecular Biology, Furin, Neuroinflammation, 030102 biochemistry & molecular biology, biology, Chemistry, Membrane Proteins, Molecular Bases of Disease, Cell Biology, Proprotein convertase, Disease Models, Animal, 030104 developmental biology, Gliosis, biology.protein, medicine.symptom, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03afb591c39bc96bbf4015cdb9362b0eTest
https://europepmc.org/articles/PMC7705308Test/

المؤلفون: J.L. Gray, Christina Bitsina, Frank von Delft, Paul Brennan, Andrew P. Thompson

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, aPKC, atypical protein kinase, dedicator of cytokinesis (DOCK), GTPase, Biology, guanosine triphosphate (GTP), Ras homologous (RHO) small GTPases, AD, Alzheimer’s disease, Biochemistry, PAK, p21-activated kinase, drug discovery, GTP Phosphohydrolases, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, GTP, guanosine triphosphate, APP, amyloid precursor protein, DOCK, Catalytic Domain, MRCK, myotonic dystrophy kinase-related CDC42-binding kinase, guanine nucleotide exchange factor, cell signaling, structural biology, Cytoskeleton, Molecular Biology, GDP, guanosine diphosphate, 030102 biochemistry & molecular biology, Drug discovery, DHR2 domain, JBC Reviews, GDI, GDP dissociation inhibitor, Cell Biology, CDOCK, dedicator of cytokinesis, Cell biology, 030104 developmental biology, Structural biology, Guanine nucleotide exchange factor, Cytokinesis, Rho Guanine Nucleotide Exchange Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a6616905efc2a2ef77da8d684aca0bTest
http://europepmc.org/articles/PMC8063744Test

المؤلفون: Lahiri, Debomoy K., Maloney, Bryan, Wang, Ruizhi

المساهمون: Medical and Molecular Genetics, School of Medicine

المصدر: PMC

مصطلحات موضوعية: cellular iron efflux, β-amyloid precursor protein, secreted APP, iron response element, Alzheimer's disease

وصف الملف: application/pdf

العلاقة: Journal of Biological Chemistry; Lahiri, D. K., Maloney, B., & Wang, R. (2019). APPealing for a role in cellular iron efflux. Journal of Biological Chemistry, 294(24), 9365–9365. https://doi.org/10.1074/jbc.L119.009216Test; 0021-9258, 1083-351X; https://hdl.handle.net/1805/24247Test

الإتاحة: https://hdl.handle.net/1805/24247Test

المؤلفون: Christine Lavoie, François Béliveau, Denis Gris, Antoine Désilets, Anthony Flamier, Shaimaa Mahmoud, Gilbert Bernier, Erwan Lanchec, Richard Leduc

مصطلحات موضوعية: 0301 basic medicine, Proteases, Recombinant Fusion Proteins, Prefrontal Cortex, Nerve Tissue Proteins, Biochemistry, ST14, Gene Expression Regulation, Enzymologic, Cell Line, Substrate Specificity, 03 medical and health sciences, Amyloid beta-Protein Precursor, Young Adult, mental disorders, Amyloid precursor protein, Cadaver, Humans, Matriptase, RNA, Messenger, Molecular Biology, Aged, Serine protease, Neurons, Amyloid beta-Peptides, biology, Chemistry, Serine Endopeptidases, P3 peptide, Age Factors, Brain, Computational Biology, Molecular Bases of Disease, Cell Biology, Peptide Fragments, Biochemistry of Alzheimer's disease, Cell biology, 030104 developmental biology, Organ Specificity, Mutation, Proteolysis, biology.protein, Mutagenesis, Site-Directed, Amyloid precursor protein secretase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368c9396d0b8827110961729388eb8f9Test
https://europepmc.org/articles/PMC5733603Test/

المؤلفون: Barbara A. Osborne, Todd E. Golde, Lisa M. Minter, Christian B. Lessard, Thomas B. Ladd, Lucio Miele, Edgardo Rodriguez, Yong Ran

المصدر: J Biol Chem

مصطلحات موضوعية: 0301 basic medicine, Biochemistry, Presenilin, Substrate Specificity, 03 medical and health sciences, Mice, Alzheimer Disease, mental disorders, Presenilin-2, medicine, Presenilin-1, CRISPR, Animals, Humans, skin and connective tissue diseases, Molecular Biology, Gene knockout, 030102 biochemistry & molecular biology, Chemistry, Hydrolysis, HEK 293 cells, Neurodegeneration, Molecular Bases of Disease, Cell Biology, medicine.disease, Transmembrane protein, Cell biology, nervous system diseases, 030104 developmental biology, HEK293 Cells, Notch proteins, nervous system, Cell culture, Gene Knockdown Techniques, Amyloid Precursor Protein Secretases, CRISPR-Cas Systems, hormones, hormone substitutes, and hormone antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86134d753e022d64c2e375061665101Test
https://europepmc.org/articles/PMC6643044Test/

المؤلفون: Kota Kikuchi, Mirai Yokomori, Yu Fujita, Kun Zou, Fujiko Ando, Chiaki Tanabe-Fujimura, Makoto Michikawa, Aoi Matsumoto, Tomoji Maeda, Shuyu Liu, Xuefeng Shen, Junjun Liu, Hiroto Komano, Hiroshi Shimokata

المصدر: J Biol Chem

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Heterozygote, Angiotensin-Converting Enzyme Inhibitors, Mice, Transgenic, Peptidyl-Dipeptidase A, Biochemistry, Neuroprotection, 03 medical and health sciences, Mice, Alzheimer Disease, Internal medicine, Renin–angiotensin system, Amyloid precursor protein, Medicine, Animals, Humans, Cognitive Dysfunction, Longitudinal Studies, Molecular Biology, Aged, Amyloid beta-Peptides, 030102 biochemistry & molecular biology, biology, business.industry, Neurotoxicity, Angiotensin-converting enzyme, Molecular Bases of Disease, Cell Biology, Middle Aged, medicine.disease, Angiotensin II, Peptide Fragments, 030104 developmental biology, Endocrinology, ACE inhibitor, biology.protein, Female, Alzheimer's disease, business, Gene Deletion, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468e6a5b7d6cf5beb600ed4b8b3e07c0Test
https://europepmc.org/articles/PMC6597817Test/

المؤلفون: Danielle K. Bailey, Haley V. Parker, Daniel J. Kosman, Adrienne C. Dlouhy, Brittany L. Steimle

مصطلحات موضوعية: 0301 basic medicine, Yellow fluorescent protein, Hephaestin, 030102 biochemistry & molecular biology, biology, Chemistry, Ferroportin, Cell Biology, Membrane transport, Biochemistry, Cell biology, 03 medical and health sciences, 030104 developmental biology, Biotinylation, biology.protein, Amyloid precursor protein, APLP1, Ceruloplasmin, Molecular Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6734e19edcce2520834c127a93cfa6Test
https://europepmc.org/articles/PMC6422103Test/

المؤلفون: Guillermo M. Garcia Osuna, Hermeto Gerber, Patrick C. Fraering, Fang Wu, Mitko Dimitrov

مصطلحات موضوعية: 0301 basic medicine, Lipid Bilayers, Nicastrin, Peptide, Biochemistry, Presenilin, 03 medical and health sciences, Amyloid beta-Protein Precursor, Inhibitory Concentration 50, 0302 clinical medicine, Protein Domains, Alzheimer Disease, medicine, Amyloid precursor protein, Humans, Histidine, Senile plaques, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Membrane Glycoproteins, biology, Cell-Free System, Lysine, Neurodegeneration, P3 peptide, Presenilins, Brain, Molecular Bases of Disease, Cell Biology, medicine.disease, Peptide Fragments, Recombinant Proteins, 3. Good health, Transmembrane domain, Zinc, 030104 developmental biology, HEK293 Cells, chemistry, Mutation, biology.protein, Amyloid Precursor Protein Secretases, Protein Multimerization, 030217 neurology & neurosurgery, Copper, Plasmids

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13faff3cd9cd64e120e76bf0b4c0bd98Test
https://europepmc.org/articles/PMC5339758Test/

المؤلفون: Yunling Wang, Hemant K. Paudel, Xike Qin

مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, Hippocampal formation, Biochemistry, Hippocampus, Gene Expression Regulation, Enzymologic, Pathogenesis, 03 medical and health sciences, Mice, 0302 clinical medicine, Neurobiology, Transcription (biology), Chlorocebus aethiops, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Molecular Biology, Transcription factor, Early Growth Response Protein 1, Regulation of gene expression, Mice, Knockout, Neurons, Gene knockdown, Amyloid beta-Peptides, biology, P3 peptide, Cell Biology, Cell biology, Rats, 030104 developmental biology, COS Cells, biology.protein, Trans-Activators, Amyloid Precursor Protein Secretases, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0458f148559919067b7ac57381e11ad2Test
https://europepmc.org/articles/PMC5064006Test/

المؤلفون: Jing Yang, G. Ed Rainger, Alexandra L. Matthews, Jasmeet S. Reyat, Michael G. Tomlinson, David A. Rogers, Alice E. Charlton, Joanna Furmston, Peter J. Noy

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, metalloprotease, Tetraspanins, ADAM10, Biochemistry, Substrate Specificity, shedding, ADAM10 Protein, Mice, 0302 clinical medicine, Tetraspanin, Cells, Cultured, platelet, ADAM Proteins, Transmembrane protein, Cell biology, Protein Transport, 030220 oncology & carcinogenesis, endothelial cell, GPVI, Blood Platelets, Surface Properties, Recombinant Fusion Proteins, Biology, Tetraspanin 29, Cell Line, 03 medical and health sciences, cell surface enzyme, Disintegrin, Human Umbilical Vein Endothelial Cells, Animals, Humans, Protein Interaction Domains and Motifs, Molecular Biology, N-cadherin, Cadherin, Cell Membrane, ADAM, Membrane Proteins, Cell Biology, Peptide Fragments, Enzyme Activation, 030104 developmental biology, tetraspanin, Membrane protein, Proteolysis, biology.protein, TspanC8, Endothelium, Vascular, Amyloid Precursor Protein Secretases, Protein Processing, Post-Translational

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34f57d5c47c84ce279f24b01794ee9bTest
http://europepmc.org/articles/PMC4751363Test