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1دورية أكاديمية
المؤلفون: Williamson, Rebecca L., Laulagnier, Karine, Miranda, André M., Fernandez, Marty A., Wolfe, Michael S., Sadoul, Rémy, Di Paolo, Gilbert
مصطلحات موضوعية: Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Arginine, Cell Line, Endosomes, Humans, Lysine, Mutation, Peptide Fragments, Presenilin-2, Proteolysis, Ubiquitination, Alzheimer disease, amyloid precursor protein (APP), amyloid- (A), endosome, intracellular processing, intracellular trafficking, lysosome, presenilin, Science & Technology
وصف الملف: application/pdf
العلاقة: http://hdl.handle.net/1822/62019Test
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2
المؤلفون: Dennis J. Selkoe, Lei Liu, Michael S. Wolfe, Bianca M. Lauro
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, FAD, familial Alzheimer’s disease, HL-1, hydrophilic loop-1, Amyloid beta, Allosteric regulation, TMD, transmembrane domain, γ-secretase, AD, Alzheimer’s disease, Biochemistry, Presenilin, DMEM, Dulbecco’s modified Eagle’s medium, Substrate Specificity, 03 medical and health sciences, Amyloid beta-Protein Precursor, FBS, fetal bovine serum, Protein Domains, APP, amyloid precursor protein, Alzheimer Disease, Amyloid precursor protein, Presenilin-1, Humans, Genetic Predisposition to Disease, Molecular Biology, γ-secretase modulator, Cells, Cultured, Aβ, GSM, γ-secretase modulator, CM, conditioned media, Amyloid beta-Peptides, 030102 biochemistry & molecular biology, biology, Chemistry, Rational design, Cell Biology, Processivity, Transmembrane protein, Cell biology, Aβ, amyloid-beta, Transmembrane domain, 030104 developmental biology, PS1, presenilin-1, Mutation, Proteolysis, biology.protein, HMW, high-molecular-weight, Amyloid Precursor Protein Secretases, Alzheimer’s disease, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534c8ae904c2652969945c575f9df201Test
http://europepmc.org/articles/PMC7961089Test -
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المؤلفون: Christine Lavoie, François Béliveau, Denis Gris, Antoine Désilets, Anthony Flamier, Shaimaa Mahmoud, Gilbert Bernier, Erwan Lanchec, Richard Leduc
مصطلحات موضوعية: 0301 basic medicine, Proteases, Recombinant Fusion Proteins, Prefrontal Cortex, Nerve Tissue Proteins, Biochemistry, ST14, Gene Expression Regulation, Enzymologic, Cell Line, Substrate Specificity, 03 medical and health sciences, Amyloid beta-Protein Precursor, Young Adult, mental disorders, Amyloid precursor protein, Cadaver, Humans, Matriptase, RNA, Messenger, Molecular Biology, Aged, Serine protease, Neurons, Amyloid beta-Peptides, biology, Chemistry, Serine Endopeptidases, P3 peptide, Age Factors, Brain, Computational Biology, Molecular Bases of Disease, Cell Biology, Peptide Fragments, Biochemistry of Alzheimer's disease, Cell biology, 030104 developmental biology, Organ Specificity, Mutation, Proteolysis, biology.protein, Mutagenesis, Site-Directed, Amyloid precursor protein secretase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368c9396d0b8827110961729388eb8f9Test
https://europepmc.org/articles/PMC5733603Test/ -
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المؤلفون: Jing Yang, G. Ed Rainger, Alexandra L. Matthews, Jasmeet S. Reyat, Michael G. Tomlinson, David A. Rogers, Alice E. Charlton, Joanna Furmston, Peter J. Noy
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, metalloprotease, Tetraspanins, ADAM10, Biochemistry, Substrate Specificity, shedding, ADAM10 Protein, Mice, 0302 clinical medicine, Tetraspanin, Cells, Cultured, platelet, ADAM Proteins, Transmembrane protein, Cell biology, Protein Transport, 030220 oncology & carcinogenesis, endothelial cell, GPVI, Blood Platelets, Surface Properties, Recombinant Fusion Proteins, Biology, Tetraspanin 29, Cell Line, 03 medical and health sciences, cell surface enzyme, Disintegrin, Human Umbilical Vein Endothelial Cells, Animals, Humans, Protein Interaction Domains and Motifs, Molecular Biology, N-cadherin, Cadherin, Cell Membrane, ADAM, Membrane Proteins, Cell Biology, Peptide Fragments, Enzyme Activation, 030104 developmental biology, tetraspanin, Membrane protein, Proteolysis, biology.protein, TspanC8, Endothelium, Vascular, Amyloid Precursor Protein Secretases, Protein Processing, Post-Translational
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34f57d5c47c84ce279f24b01794ee9bTest
http://europepmc.org/articles/PMC4751363Test -
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المؤلفون: Neha Sawhney, James C. Powell, Vishal Agrawal, Jyoti Chhibber-Goel, Emer Hickey, Justin V. McCarthy, Caroline Coleman-Vaughan
مصطلحات موضوعية: 0301 basic medicine, MAP Kinase Kinase 4, medicine.medical_treatment, Chemokine CXCL1, Apoptosis, Biochemistry, Regulated Intramembrane Proteolysis, Presenilin, Cell Line, 03 medical and health sciences, medicine, Animals, Humans, Receptor, Molecular Biology, Gamma secretase, Mice, Knockout, biology, Chemistry, Tumor Necrosis Factor-alpha, Presenilins, Cell Biology, respiratory system, Cell biology, Enzyme Activation, Mice, Inbred C57BL, 030104 developmental biology, Cytokine, Ectodomain, Receptors, Tumor Necrosis Factor, Type I, Proteolysis, biology.protein, Signal transduction, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Gene Deletion, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3541ecc5676d747d20a753fae8a749dTest
https://europepmc.org/articles/PMC4786730Test/ -
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المؤلفون: Robert E. Burke, Nikolai Kholodilov, Neelam Shahani, William Pryor, Gopal Thinakaran, Supriya Swarnkar, Srinivasa Subramaniam
مصطلحات موضوعية: Amyloid, Regulator, GTPase, Biology, Biochemistry, Gene Expression Regulation, Enzymologic, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, mental disorders, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Molecular Biology, PI3K/AKT/mTOR pathway, Monomeric GTP-Binding Proteins, Gene knockdown, Neuropeptides, Brain, Cell Biology, Cell biology, HEK293 Cells, Proteolysis, biology.protein, Ras Homolog Enriched in Brain Protein, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, RHEB, Signal Transduction, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad0587965f245e0cb9a45622e7c40cbTest
https://europepmc.org/articles/PMC3937651Test/ -
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المؤلفون: Yongcheng Wang, Yi Xue, Sangwon Lee, Ya Ha
مصطلحات موضوعية: Proteolysis, Mutation, Missense, Crystallography, X-Ray, Biochemistry, Amyloid beta-Protein Precursor, mental disorders, medicine, Amyloid precursor protein, Humans, APLP1, Binding site, Site-directed mutagenesis, Molecular Biology, biology, medicine.diagnostic_test, Cell Biology, Heparin, Protein Structure, Tertiary, HEK293 Cells, Amino Acid Substitution, Protein Structure and Folding, biology.protein, Biophysics, Additions and Corrections, Signal transduction, Amyloid Precursor Protein Secretases, Protein Multimerization, Amyloid precursor protein secretase, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff74cf86e9d0e0e6380cbccc325e6e40Test
https://europepmc.org/articles/PMC3843088Test/ -
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مصطلحات موضوعية: ADAM10, Immunology, Protein degradation, Biology, Cleavage (embryo), Biochemistry, ADAM10 Protein, Humans, Tyrosine, Receptors, Immunologic, Molecular Biology, Inflammation, CD47, NF-kappa B, Membrane Proteins, Cell Biology, Molecular biology, Antigens, Differentiation, Transmembrane protein, ADAM Proteins, STAT1 Transcription Factor, Proteolysis, Phosphorylation, Signal transduction, Amyloid Precursor Protein Secretases, HeLa Cells, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf2156df7d85abc6a10a8711334e1f0Test
https://europepmc.org/articles/PMC4692235Test/ -
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المؤلفون: Magali Prigent, Marie-Hélène Cuif, Andrés Alcover, Amel Rayah, Monique Arpin, Jean Kanellopoulos, Rodolphe Auger, Amaria Darmellah, Cécile Delarasse
مصطلحات موضوعية: MAPK/ERK pathway, Moesin, macromolecular substances, Biochemistry, Amyloid beta-Protein Precursor, Mice, Phosphatidylinositol 3-Kinases, Ezrin, Radixin, Cell Line, Tumor, Amyloid precursor protein, Animals, Humans, Molecular Biology, Mitogen-Activated Protein Kinase 1, rho-Associated Kinases, Mitogen-Activated Protein Kinase 3, biology, Purinergic receptor, Microfilament Proteins, Membrane Proteins, Cell Biology, Cell biology, Cytoskeletal Proteins, HEK293 Cells, Ectodomain, Proteolysis, biology.protein, Receptors, Purinergic P2X7, Amyloid precursor protein secretase, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef43f12367cbfe50d1bef926d78b98f4Test
https://europepmc.org/articles/PMC3464564Test/ -
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المؤلفون: Yun Wang, Daniel R. Dries, Gang Yu, Cong Yu, Sanjiv J. Shah, Chantelle F. Sephton, Jin Jiang, Bhooma Srinivasan, Colleen M. Dewey, Sheu Fen Lee, Bing Wang
مصطلحات موضوعية: Proteolysis, Notch signaling pathway, Biochemistry, Mice, medicine, Animals, Humans, RNA, Small Interfering, Molecular Biology, medicine.diagnostic_test, biology, Base Sequence, Receptors, Notch, Hydrolysis, Metalloendopeptidases, Cell Biology, Cell biology, Notch proteins, biology.protein, Enzymology, Cyclin-dependent kinase 8, RNA Interference, biology.gene, Signal transduction, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Mitochondrial intermediate peptidase, Intracellular, HeLa Cells, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3be53d5865916e88c5dc05a5ce17efbTest
https://europepmc.org/articles/PMC3149338Test/