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1
المؤلفون: Dennis J. Selkoe, Lei Liu, Michael S. Wolfe, Bianca M. Lauro
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, FAD, familial Alzheimer’s disease, HL-1, hydrophilic loop-1, Amyloid beta, Allosteric regulation, TMD, transmembrane domain, γ-secretase, AD, Alzheimer’s disease, Biochemistry, Presenilin, DMEM, Dulbecco’s modified Eagle’s medium, Substrate Specificity, 03 medical and health sciences, Amyloid beta-Protein Precursor, FBS, fetal bovine serum, Protein Domains, APP, amyloid precursor protein, Alzheimer Disease, Amyloid precursor protein, Presenilin-1, Humans, Genetic Predisposition to Disease, Molecular Biology, γ-secretase modulator, Cells, Cultured, Aβ, GSM, γ-secretase modulator, CM, conditioned media, Amyloid beta-Peptides, 030102 biochemistry & molecular biology, biology, Chemistry, Rational design, Cell Biology, Processivity, Transmembrane protein, Cell biology, Aβ, amyloid-beta, Transmembrane domain, 030104 developmental biology, PS1, presenilin-1, Mutation, Proteolysis, biology.protein, HMW, high-molecular-weight, Amyloid Precursor Protein Secretases, Alzheimer’s disease, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534c8ae904c2652969945c575f9df201Test
http://europepmc.org/articles/PMC7961089Test -
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المؤلفون: Michael R. Sierks, Ping He, Philip Schulz
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Biochemistry, Mice, Amyloid precursor protein, scFv, single chain antibody variable domain fragment, Neurons, biology, Chemistry, oligomeric beta amyloid, Neurogenesis, DCX, doublecortin, Brain, Editors' Pick, Alzheimer's disease, Cell biology, BBB, blood brain barrier, medicine.anatomical_structure, Disease Progression, SYP, synaptophysin, AD, Alzheimer's disease, Intracellular, Research Article, Genetically modified mouse, Aβ, amyloid β, rAAV, recombinant human adeno-associated virus, transgenic mice, Blood–brain barrier, Protein Aggregation, Pathological, 03 medical and health sciences, MAP2, microtubule-associated protein 2, Alzheimer Disease, APP, amyloid precursor protein, medicine, Animals, Humans, ApoB, apolipoprotein B, Molecular Biology, Neuroinflammation, Amyloid beta-Peptides, 030102 biochemistry & molecular biology, GFAP, glial fibrillary acidic protein, Cell Biology, medicine.disease, neuron, Disease Models, Animal, ND, nondementia, 030104 developmental biology, single-chain antibody, biology.protein, Neuron, Single-Chain Antibodies
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb895cc10e4d58759d80fdf7e5d922ccTest
http://europepmc.org/articles/PMC7948963Test -
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المؤلفون: Bettina Platt, Jochen Vogl, Nikolay Solovyev, Karima Schwab, Franz Theuring, Elizabeth Griffin, Frank Vanhaecke, Andrea Raab, Marta Costas-Rodríguez, Ahmed H. El-Khatib
المصدر: The Journal of Biological Chemistry
JOURNAL OF BIOLOGICAL CHEMISTRYمصطلحات موضوعية: 0301 basic medicine, Male, FTD, frontotemporal dementia, COPPER, Gene Expression, Protein aggregation, Biochemistry, CSF, cerebrospinal fluid, total element determination, ZINC, Amyloid beta-Protein Precursor, Mice, iron, Medicine and Health Sciences, Amyloid precursor protein, tau, Transgenes, Phosphorylation, BBB, blood–brain barrier, Isotope analysis, TRANSGENIC MICE, biology, zinc, MOUSE MODEL, AMYLOID-BETA, amyloid-beta, Chemistry, isotopic analysis, Tauopathy, ICP-MS, inductively coupled plasma–mass spectrometry, NEUROFIBRILLARY TANGLES, Alzheimer’s disease, Research Article, Genetically modified mouse, Amyloid beta, brain, Iron, chemistry.chemical_element, Mice, Transgenic, tau Proteins, Zinc, AD, Alzheimer’s disease, Presenilin, 03 medical and health sciences, Protein Aggregates, APP, amyloid precursor protein, Alzheimer Disease, medicine, Presenilin-1, Animals, multicollector inductively coupled plasma–mass spectrometry (ICP-MS), Molecular Biology, multi-collector inductively coupled plasma-mass spectrometry (ICP-MS), 030102 biochemistry & molecular biology, BLOOD-BRAIN-BARRIER, MUTATIONS, Spectrophotometry, Atomic, Biology and Life Sciences, Cell Biology, medicine.disease, WT, wild-type, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, METAL-IONS, chemistry, copper, Mutation, biology.protein, MC-ICP-MS, multicollector sector field inductively coupled plasma–mass spectrometry, serum
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17246254d5ee9ebbd7fa8a442af2e873Test
http://europepmc.org/articles/PMC7949056Test -
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المؤلفون: Terrence Town, Tomotaka Yokoo, Takashi Mori, Masahiro Maeda, Jun Tan, Naoki Koyama, Darrell Sawmiller, Tatsuya Segawa
المصدر: J Biol Chem
مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, ADAM10, Mice, Transgenic, medicine.disease_cause, Biochemistry, Presenilin, 03 medical and health sciences, ADAM10 Protein, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, Gallic Acid, mental disorders, medicine, Presenilin-1, Animals, Aspartic Acid Endopeptidases, Humans, Molecular Biology, Furin, Neuroinflammation, 030102 biochemistry & molecular biology, biology, Chemistry, Membrane Proteins, Molecular Bases of Disease, Cell Biology, Proprotein convertase, Disease Models, Animal, 030104 developmental biology, Gliosis, biology.protein, medicine.symptom, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03afb591c39bc96bbf4015cdb9362b0eTest
https://europepmc.org/articles/PMC7705308Test/ -
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المؤلفون: Christine Lavoie, François Béliveau, Denis Gris, Antoine Désilets, Anthony Flamier, Shaimaa Mahmoud, Gilbert Bernier, Erwan Lanchec, Richard Leduc
مصطلحات موضوعية: 0301 basic medicine, Proteases, Recombinant Fusion Proteins, Prefrontal Cortex, Nerve Tissue Proteins, Biochemistry, ST14, Gene Expression Regulation, Enzymologic, Cell Line, Substrate Specificity, 03 medical and health sciences, Amyloid beta-Protein Precursor, Young Adult, mental disorders, Amyloid precursor protein, Cadaver, Humans, Matriptase, RNA, Messenger, Molecular Biology, Aged, Serine protease, Neurons, Amyloid beta-Peptides, biology, Chemistry, Serine Endopeptidases, P3 peptide, Age Factors, Brain, Computational Biology, Molecular Bases of Disease, Cell Biology, Peptide Fragments, Biochemistry of Alzheimer's disease, Cell biology, 030104 developmental biology, Organ Specificity, Mutation, Proteolysis, biology.protein, Mutagenesis, Site-Directed, Amyloid precursor protein secretase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368c9396d0b8827110961729388eb8f9Test
https://europepmc.org/articles/PMC5733603Test/ -
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المؤلفون: Barbara A. Osborne, Todd E. Golde, Lisa M. Minter, Christian B. Lessard, Thomas B. Ladd, Lucio Miele, Edgardo Rodriguez, Yong Ran
المصدر: J Biol Chem
مصطلحات موضوعية: 0301 basic medicine, Biochemistry, Presenilin, Substrate Specificity, 03 medical and health sciences, Mice, Alzheimer Disease, mental disorders, Presenilin-2, medicine, Presenilin-1, CRISPR, Animals, Humans, skin and connective tissue diseases, Molecular Biology, Gene knockout, 030102 biochemistry & molecular biology, Chemistry, Hydrolysis, HEK 293 cells, Neurodegeneration, Molecular Bases of Disease, Cell Biology, medicine.disease, Transmembrane protein, Cell biology, nervous system diseases, 030104 developmental biology, HEK293 Cells, Notch proteins, nervous system, Cell culture, Gene Knockdown Techniques, Amyloid Precursor Protein Secretases, CRISPR-Cas Systems, hormones, hormone substitutes, and hormone antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86134d753e022d64c2e375061665101Test
https://europepmc.org/articles/PMC6643044Test/ -
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المؤلفون: Danielle K. Bailey, Haley V. Parker, Daniel J. Kosman, Adrienne C. Dlouhy, Brittany L. Steimle
مصطلحات موضوعية: 0301 basic medicine, Yellow fluorescent protein, Hephaestin, 030102 biochemistry & molecular biology, biology, Chemistry, Ferroportin, Cell Biology, Membrane transport, Biochemistry, Cell biology, 03 medical and health sciences, 030104 developmental biology, Biotinylation, biology.protein, Amyloid precursor protein, APLP1, Ceruloplasmin, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6734e19edcce2520834c127a93cfa6Test
https://europepmc.org/articles/PMC6422103Test/ -
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مصطلحات موضوعية: 0301 basic medicine, Lipid Bilayers, Nicastrin, Peptide, Biochemistry, Presenilin, 03 medical and health sciences, Amyloid beta-Protein Precursor, Inhibitory Concentration 50, 0302 clinical medicine, Protein Domains, Alzheimer Disease, medicine, Amyloid precursor protein, Humans, Histidine, Senile plaques, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Membrane Glycoproteins, biology, Cell-Free System, Lysine, Neurodegeneration, P3 peptide, Presenilins, Brain, Molecular Bases of Disease, Cell Biology, medicine.disease, Peptide Fragments, Recombinant Proteins, 3. Good health, Transmembrane domain, Zinc, 030104 developmental biology, HEK293 Cells, chemistry, Mutation, biology.protein, Amyloid Precursor Protein Secretases, Protein Multimerization, 030217 neurology & neurosurgery, Copper, Plasmids
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13faff3cd9cd64e120e76bf0b4c0bd98Test
https://europepmc.org/articles/PMC5339758Test/ -
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المؤلفون: Neha Sawhney, James C. Powell, Vishal Agrawal, Jyoti Chhibber-Goel, Emer Hickey, Justin V. McCarthy, Caroline Coleman-Vaughan
مصطلحات موضوعية: 0301 basic medicine, MAP Kinase Kinase 4, medicine.medical_treatment, Chemokine CXCL1, Apoptosis, Biochemistry, Regulated Intramembrane Proteolysis, Presenilin, Cell Line, 03 medical and health sciences, medicine, Animals, Humans, Receptor, Molecular Biology, Gamma secretase, Mice, Knockout, biology, Chemistry, Tumor Necrosis Factor-alpha, Presenilins, Cell Biology, respiratory system, Cell biology, Enzyme Activation, Mice, Inbred C57BL, 030104 developmental biology, Cytokine, Ectodomain, Receptors, Tumor Necrosis Factor, Type I, Proteolysis, biology.protein, Signal transduction, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Gene Deletion, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3541ecc5676d747d20a753fae8a749dTest
https://europepmc.org/articles/PMC4786730Test/ -
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المؤلفون: Peter A. Argenta, Kristin L.M. Boylan, Amy P.N. Skubitz, Rachel Heinze, Bruce Walcheck, Petra C. Buchanan, Melissa A. Geller
مصطلحات موضوعية: 0301 basic medicine, endocrine system diseases, MAP Kinase Signaling System, Proto-Oncogene Proteins c-jun, ADAM10, ADAM17 Protein, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, ADAM10 Protein, Protein Domains, Ovarian carcinoma, Cell Line, Tumor, Lysophosphatidic acid, medicine, Humans, RNA, Messenger, RNA, Neoplasm, Neoplasm Metastasis, Receptor, Extracellular Signal-Regulated MAP Kinases, Molecular Biology, Ovarian Neoplasms, Chemistry, Cell adhesion molecule, Membrane Proteins, Cell Biology, medicine.disease, 030104 developmental biology, Ectodomain, Cancer research, Female, Signal transduction, Amyloid Precursor Protein Secretases, Ovarian cancer, Cell Adhesion Molecules, Proto-Oncogene Proteins c-akt
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7be6b0ac9870f3af5c5e4035264c25bTest
https://europepmc.org/articles/PMC5391762Test/