يعرض 1 - 10 نتائج من 29 نتيجة بحث عن '"Amyloid-Precursor-Protein"', وقت الاستعلام: 1.08s تنقيح النتائج
  1. 1
    Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice

    المؤلفون: Terrence Town, Tomotaka Yokoo, Takashi Mori, Masahiro Maeda, Jun Tan, Naoki Koyama, Darrell Sawmiller, Tatsuya Segawa

    المصدر: J Biol Chem

    مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, ADAM10, Mice, Transgenic, medicine.disease_cause, Biochemistry, Presenilin, 03 medical and health sciences, ADAM10 Protein, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, Gallic Acid, mental disorders, medicine, Presenilin-1, Animals, Aspartic Acid Endopeptidases, Humans, Molecular Biology, Furin, Neuroinflammation, 030102 biochemistry & molecular biology, biology, Chemistry, Membrane Proteins, Molecular Bases of Disease, Cell Biology, Proprotein convertase, Disease Models, Animal, 030104 developmental biology, Gliosis, biology.protein, medicine.symptom, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Oxidative stress

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03afb591c39bc96bbf4015cdb9362b0eTest
    https://europepmc.org/articles/PMC7705308Test/


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  2. 2
    The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide

    المؤلفون: Christine Lavoie, François Béliveau, Denis Gris, Antoine Désilets, Anthony Flamier, Shaimaa Mahmoud, Gilbert Bernier, Erwan Lanchec, Richard Leduc

    مصطلحات موضوعية: 0301 basic medicine, Proteases, Recombinant Fusion Proteins, Prefrontal Cortex, Nerve Tissue Proteins, Biochemistry, ST14, Gene Expression Regulation, Enzymologic, Cell Line, Substrate Specificity, 03 medical and health sciences, Amyloid beta-Protein Precursor, Young Adult, mental disorders, Amyloid precursor protein, Cadaver, Humans, Matriptase, RNA, Messenger, Molecular Biology, Aged, Serine protease, Neurons, Amyloid beta-Peptides, biology, Chemistry, Serine Endopeptidases, P3 peptide, Age Factors, Brain, Computational Biology, Molecular Bases of Disease, Cell Biology, Peptide Fragments, Biochemistry of Alzheimer's disease, Cell biology, 030104 developmental biology, Organ Specificity, Mutation, Proteolysis, biology.protein, Mutagenesis, Site-Directed, Amyloid precursor protein secretase

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368c9396d0b8827110961729388eb8f9Test
    https://europepmc.org/articles/PMC5733603Test/


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  3. 3
    γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling*

    المؤلفون: Neha Sawhney, James C. Powell, Vishal Agrawal, Jyoti Chhibber-Goel, Emer Hickey, Justin V. McCarthy, Caroline Coleman-Vaughan

    مصطلحات موضوعية: 0301 basic medicine, MAP Kinase Kinase 4, medicine.medical_treatment, Chemokine CXCL1, Apoptosis, Biochemistry, Regulated Intramembrane Proteolysis, Presenilin, Cell Line, 03 medical and health sciences, medicine, Animals, Humans, Receptor, Molecular Biology, Gamma secretase, Mice, Knockout, biology, Chemistry, Tumor Necrosis Factor-alpha, Presenilins, Cell Biology, respiratory system, Cell biology, Enzyme Activation, Mice, Inbred C57BL, 030104 developmental biology, Cytokine, Ectodomain, Receptors, Tumor Necrosis Factor, Type I, Proteolysis, biology.protein, Signal transduction, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Gene Deletion, Signal Transduction

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3541ecc5676d747d20a753fae8a749dTest
    https://europepmc.org/articles/PMC4786730Test/


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  4. 4
    Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function*

    المؤلفون: Barry I. Hudson, Evis Harja, Ralf Landgraf, Joel Jules, Tae Kyoung Kwak, A. Braley

    مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, medicine.medical_specialty, Cell signaling, endocrine system diseases, Biochemistry, RAGE (receptor), 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, cardiovascular diseases, Molecular Biology, biology, Actin cytoskeleton reorganization, nutritional and metabolic diseases, Cell migration, Cell Biology, Cell biology, 030104 developmental biology, Endocrinology, Ectodomain, 030220 oncology & carcinogenesis, biology.protein, cardiovascular system, Signal transduction, Amyloid precursor protein secretase, human activities, Signal Transduction

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0321739f8cc9e74ef8e612b0d56150Test
    https://europepmc.org/articles/PMC4933258Test/


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  5. 5
    Rheb GTPase Regulates β-Secretase Levels and Amyloid β Generation*

    المؤلفون: Robert E. Burke, Nikolai Kholodilov, Neelam Shahani, William Pryor, Gopal Thinakaran, Supriya Swarnkar, Srinivasa Subramaniam

    مصطلحات موضوعية: Amyloid, Regulator, GTPase, Biology, Biochemistry, Gene Expression Regulation, Enzymologic, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, mental disorders, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Molecular Biology, PI3K/AKT/mTOR pathway, Monomeric GTP-Binding Proteins, Gene knockdown, Neuropeptides, Brain, Cell Biology, Cell biology, HEK293 Cells, Proteolysis, biology.protein, Ras Homolog Enriched in Brain Protein, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, RHEB, Signal Transduction, Protein Binding

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad0587965f245e0cb9a45622e7c40cbTest
    https://europepmc.org/articles/PMC3937651Test/


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  6. 6
    Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate

    المؤلفون: Yongcheng Wang, Yi Xue, Sangwon Lee, Ya Ha

    مصطلحات موضوعية: Proteolysis, Mutation, Missense, Crystallography, X-Ray, Biochemistry, Amyloid beta-Protein Precursor, mental disorders, medicine, Amyloid precursor protein, Humans, APLP1, Binding site, Site-directed mutagenesis, Molecular Biology, biology, medicine.diagnostic_test, Cell Biology, Heparin, Protein Structure, Tertiary, HEK293 Cells, Amino Acid Substitution, Protein Structure and Folding, biology.protein, Biophysics, Additions and Corrections, Signal transduction, Amyloid Precursor Protein Secretases, Protein Multimerization, Amyloid precursor protein secretase, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff74cf86e9d0e0e6380cbccc325e6e40Test
    https://europepmc.org/articles/PMC3843088Test/


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  7. 7
    α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death

    المؤلفون: Claire Sunyach, Charlotte Bauer, Sergio T. Ferreira, Aurelie Thevenet, Marie-Victoire Guillot-Sestier, Maria Paz Marzolo, Frédéric Checler

    المساهمون: Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Millennium Nucleus for Regenerative Biology (MINREB), Pontificia Universidad Católica de Chile (UC)

    المصدر: Journal of Biological Chemistry
    Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (7), pp.5021-32. ⟨10.1074/jbc.M111.323626⟩
    JOURNAL OF BIOLOGICAL CHEMISTRY
    Artículos CONICYT
    CONICYT Chile
    instacron:CONICYT

    مصطلحات موضوعية: p53, MESH: Cell Death, MESH: Neurons, MESH: Cricetinae, Biochemistry, Transactivation, Aβ Oligomers, Amyloid beta-Protein Precursor, Mice, 0302 clinical medicine, MESH: Cricetulus, MESH: Amyloid beta-Protein Precursor, Cricetinae, MESH: Caspase 3, Amyloid precursor protein, MESH: Animals, Enzyme Inhibitors, Neurons, 0303 health sciences, biology, Cell Death, MESH: Peptides, MESH: Protein Multimerization, Caspase 3, Chinese hamster ovary cell, 030302 biochemistry & molecular biology, Molecular Bases of Disease, Cell biology, MESH: Enzyme Inhibitors, MESH: HEK293 Cells, Secretases, Additions and Corrections, Alzheimer's disease, sAPPα, Programmed cell death, Amyloid, MESH: Enzyme Activation, Prions, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, CHO Cells, 03 medical and health sciences, Cricetulus, MESH: CHO Cells, Alzheimer Disease, medicine, Animals, Humans, MESH: PrPC Proteins, PrPC Proteins, N1 Fragment, Molecular Biology, MESH: Mice, 030304 developmental biology, MESH: Humans, HEK 293 cells, Cell Biology, medicine.disease, Staurosporine, Enzyme Activation, HEK293 Cells, MESH: Amyloid Precursor Protein Secretases, biology.protein, MESH: Staurosporine, Amyloid Precursor Protein Secretases, Protein Multimerization, Peptides, Amyloid precursor protein secretase, 030217 neurology & neurosurgery, MESH: Alzheimer Disease

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9bfc3e54618ef29558dcc4270b42aeTest
    https://europepmc.org/articles/PMC3774388Test/


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  8. 8
    Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality

    المؤلفون: Sergio Villordo, Laura Morelli, Maria Celeste Leal, Natalia Magnani, Eduardo M. Castaño, Pablo Evelson, Cristina Marino Buslje

    المصدر: CONICET Digital (CONICET)
    Consejo Nacional de Investigaciones Científicas y Técnicas
    instacron:CONICET

    مصطلحات موضوعية: IDE, Nerve Tissue Proteins, Mitochondrion, insulin-degrading enzyme isoform, Insulysin, Biochemistry, purl.org/becyt/ford/1 [https], Mitochondrial Proteins, Rats, Sprague-Dawley, Ciencias Biológicas, Genética y Herencia, Alzheimer Disease, medicine, Insulin-degrading enzyme, Animals, Humans, NRF1, purl.org/becyt/ford/1.6 [https], Molecular Biology, Heat-Shock Proteins, amyloid β peptide, Amyloid beta-Peptides, biology, Nuclear Respiratory Factor 1, Catabolism, Neurodegeneration, Brain, RNA-Binding Proteins, Cell Biology, medicine.disease, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Mitochondria, Rats, Cell biology, HEK293 Cells, Mitochondrial biogenesis, biology.protein, Amyloid Precursor Protein Secretases, Alzheimer disease, Amyloid precursor protein secretase, CIENCIAS NATURALES Y EXACTAS, HeLa Cells, Transcription Factors

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad3665ae5021e2109f29d51d66acf3aTest
    http://www.jbc.org/content/288/18/12920.longTest


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  9. 9
    Ezrin/Radixin/Moesin Are Required for the Purinergic P2X7 Receptor (P2X7R)-dependent Processing of the Amyloid Precursor Protein*

    المؤلفون: Magali Prigent, Marie-Hélène Cuif, Andrés Alcover, Amel Rayah, Monique Arpin, Jean Kanellopoulos, Rodolphe Auger, Amaria Darmellah, Cécile Delarasse

    مصطلحات موضوعية: MAPK/ERK pathway, Moesin, macromolecular substances, Biochemistry, Amyloid beta-Protein Precursor, Mice, Phosphatidylinositol 3-Kinases, Ezrin, Radixin, Cell Line, Tumor, Amyloid precursor protein, Animals, Humans, Molecular Biology, Mitogen-Activated Protein Kinase 1, rho-Associated Kinases, Mitogen-Activated Protein Kinase 3, biology, Purinergic receptor, Microfilament Proteins, Membrane Proteins, Cell Biology, Cell biology, Cytoskeletal Proteins, HEK293 Cells, Ectodomain, Proteolysis, biology.protein, Receptors, Purinergic P2X7, Amyloid precursor protein secretase, Signal Transduction

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef43f12367cbfe50d1bef926d78b98f4Test
    https://europepmc.org/articles/PMC3464564Test/


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  10. 10
    The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-β and in the Cortex of Aged Rats*

    المؤلفون: Aoife Gowran, Andrew G. Bowie, Sinead E. Keating, Riffat Tanveer, Veronica A. Campbell, Janis Noonan

    مصطلحات موضوعية: Male, medicine.medical_specialty, Aging, Polyunsaturated Alkamides, 2-Arachidonoylglycerol, Notch signaling pathway, Arachidonic Acids, Biochemistry, Hippocampus, Gene Expression Regulation, Enzymologic, Glycerides, chemistry.chemical_compound, Neurobiology, Alzheimer Disease, Internal medicine, Amyloid precursor protein, medicine, Animals, Rats, Wistar, Receptor, Notch1, Molecular Biology, Notch 1, Cells, Cultured, Cerebral Cortex, Neurons, Amyloid beta-Peptides, Membrane Glycoproteins, biology, Neurogenesis, Cell Biology, Anandamide, Endocannabinoid system, Peptide Fragments, Rats, Up-Regulation, Endocrinology, chemistry, Benzamides, biology.protein, lipids (amino acids, peptides, and proteins), Carbamates, Amyloid Precursor Protein Secretases, Neuroscience, Amyloid precursor protein secretase, Endocannabinoids, Signal Transduction

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d537a406c90fcf07c4afb7849396a8dcTest
    https://europepmc.org/articles/PMC3464574Test/


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