دورية أكاديمية
Graphene/β-Tricalcium Phosphate Composite Scaffold Facilitates the Repairment of Cartilage Defect in Rabbit Knee Joint
| العنوان: | Graphene/β-Tricalcium Phosphate Composite Scaffold Facilitates the Repairment of Cartilage Defect in Rabbit Knee Joint |
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| المؤلفون: | Huang, Wendong, Liao, Yong, Yuan, Xiaolu, Huang, Jianhui, Chen, Ya, Zhao, Binxiu |
| المصدر: | Journal of Biomedical Nanotechnology ; volume 19, issue 12, page 2129-2136 ; ISSN 1550-7033 |
| بيانات النشر: | American Scientific Publishers |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Pharmaceutical Science, General Materials Science, Biomedical Engineering, Medicine (miscellaneous), Bioengineering |
| الوصف: | Our research aims to evaluate the repairment of graphene/ β -tricalcium phosphate (G/ β -TCP) composite scaffold on cartilage defect in rabbit knee joints. The G/ β -TCP composite material containing BMSCs was surgically implanted into the femoral condyle of a full-thickness cartilage defect model in rabbits. XRD showed that no difference in the X-ray diffraction characteristics was observed between G/ β -TCP and β -TCP. The biomechanical test claimed that the graphene doped β -TCP material processed higher mechanical strength. Scanning electron microscopy showed that the surface of G/ β -TCP material was smoother and the texture was denser. The scaffold combined with BMSCs was transplanted into the full-thickness cartilage defect rabbit model and the results showed that the serum CRP level increased only 1 month after implantation, and the Cr level increased at 2 months after implantation, while G/ β -TCP material showed rare significant pathological changes on the liver, spleen, kidney, brain, and soft tissue around the operation, which indicated a promising biocompatibility. The expression of type I and II collagen in the cartilage tissue of G/ β -TCP treated rabbits was dramatically elevated compared to β -TCP at 2 and 3 months after implantation. Collectively, the G/ β -TCP composite scaffold facilitated the repairment of cartilage defects in the rabbit knee joints. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1166/jbn.2023.3715 |
| الإتاحة: | https://doi.org/10.1166/jbn.2023.3715Test https://www.ingentaconnect.com/content/asp/jbn/2023/00000019/00000012/art00011Test |
| رقم الانضمام: | edsbas.DD1651B1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1166/jbn.2023.3715 |
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