Racial discrimination and telomere shortening among African Americans: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
| العنوان: | Racial discrimination and telomere shortening among African Americans: The Coronary Artery Risk Development in Young Adults (CARDIA) Study |
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| المؤلفون: | Gene H. Brody, Elissa S. Epel, Karen A. Matthews, Erica C Spears, David H. Chae, Tiffany Yip, Jue Lin, Natalie Slopen, Eli Puterman, Thomas E. Fuller-Rowell, Nancy E. Adler, Connor D. Martz, Yijie Wang |
| المصدر: | Health Psychol Health psychology : official journal of the Division of Health Psychology, American Psychological Association, vol 39, iss 3 |
| بيانات النشر: | American Psychological Association (APA), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, media_common.quotation_subject, Coronary Artery Disease, Cardiovascular, Medical and Health Sciences, Racism, Article, Education, leukocyte telomere length, Young Adult, 03 medical and health sciences, Behavioral and Social Science, Genetics, Humans, Medicine, Chronic stress, Young adult, Heart Disease - Coronary Heart Disease, Telomere Shortening, Applied Psychology, media_common, African Americans, Change score, 030505 public health, Multivariable linear regression, business.industry, Psychology and Cognitive Sciences, Telomere, Black or African American, Psychiatry and Mental health, Heart Disease, medicine.anatomical_structure, Psychosocial stress, Female, Public Health, 0305 other medical science, business, racial discrimination, Demography, Artery |
| الوصف: | Objective Telomeres are protective sequences of DNA capping the ends of chromosomes that shorten over time. Leukocyte telomere length (LTL) is posited to reflect the replicative history of cells and general systemic aging of the organism. Chronic stress exposure leads to accelerated LTL shortening, which has been linked to increased susceptibility to and faster progression of aging-related diseases. This study examined longitudinal associations between LTL and experiences of racial discrimination, a qualitatively unique source of minority psychosocial stress, among African Americans. Method Data are from 391 African Americans in the Coronary Artery Risk Development in Young Adults (CARDIA) Telomere Ancillary Study. We examined the number of domains in which racial discrimination was experienced in relation to LTL collected in Years 15 and 25 (Y15: 2000/2001; Y25: 2010/2011). Multivariable linear regression examined if racial discrimination was associated with LTL. Latent change score analysis (LCS) examined changes in racial discrimination and LTL in relation to one another. Results Controlling for racial discrimination at Y15, multivariable linear regression analyses indicated that racial discrimination at Y25 was significantly associated with LTL at Y25. This relationship remained robust after adjusting for LTL at Y15 (b = -.019, p = .015). Consistent with this finding, LCS revealed that increases in experiences of racial discrimination were associated with faster 10-year LTL shortening (b = -.019, p = .015). Conclusions This study adds to evidence that racial discrimination contributes to accelerated physiologic weathering and health declines among African Americans through its impact on biological systems, including via its effects on telomere attrition. (PsycINFO Database Record (c) 2020 APA, all rights reserved). |
| وصف الملف: | application/pdf |
| تدمد: | 1930-7810 0278-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f04e3b263f799e2f796ad745d00badfTest https://doi.org/10.1037/hea0000832Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f04e3b263f799e2f796ad745d00badf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19307810 02786133 |
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