دورية أكاديمية
Genome-wide linkage and follow-up association study of postpartum mood symptoms
العنوان: | Genome-wide linkage and follow-up association study of postpartum mood symptoms |
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المؤلفون: | Mahon, P. B., Payne, J. L., MacKinnon, D. F., Mondimore, F. M., Goes, F. S., Schweizer, B., Jancic, D., Coryell, W. H., Holmans, Peter Alan, Shi, J., Knowles, J. A., Scheftner, W. A., Weissman, M. M., Levinson, D. F., DePaulo, J. R., Zandi, P. P., Potash, J. B. |
بيانات النشر: | American Psychiatric Publishing American Psychiatric Association |
سنة النشر: | 2009 |
مصطلحات موضوعية: | RZ Other systems of medicine, demo, socio |
الوصف: | Objective: Family studies have suggested that postpartum mood symptoms might have a partly genetic etiology. The authors used a genome-wide linkage analysis to search for chromosomal regions that harbor genetic variants conferring susceptibility for such symptoms. The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms. Method: Subjects were ascertained from two studies: the NIMH Genetics Initiative Bipolar Disorder project and the Genetics of Recurrent Early-Onset Depression. Subjects included women with a history of pregnancy, any mood disorder, and information about postpartum symptoms. In the linkage study, 1,210 women met criteria (23% with postpartum symptoms), and 417 microsatellite markers were analyzed in multipoint allele sharing analyses. For the association study, 759 women met criteria (25% with postpartum symptoms), and 16,916 SNPs in the regions of the best linkage peaks were assessed for association with postpartum symptoms. Results: The maximum linkage peak for postpartum symptoms occurred on chromosome 1q21.3-q32.1, with a chromosome-wide significant likelihood ratio Z score (ZLR) of 2.93 (permutation p=0.02). This was a significant increase over the baseline ZLR of 0.32 observed at this locus among all women with a mood disorder (permutation p=0.004). Suggestive linkage was also found on 9p24.3-p22.3 (ZLR=2.91). In the fine-mapping study, the strongest implicated gene was HMCN1 (nominal p=0.00017), containing four estrogen receptor binding sites, although this was not region-wide significant. Conclusions: This is the first study to examine the genetic etiology of postpartum mood symptoms using genome-wide data. The results suggest that genetic variations on chromosomes 1q21.3-q32.1 and 9p24.3-p22.3 may increase susceptibility to postpartum mood symptoms. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | unknown |
العلاقة: | https://orca.cardiff.ac.uk/id/eprint/28666Test/ |
الإتاحة: | https://orca.cardiff.ac.uk/id/eprint/28666Test/ |
حقوق: | undefined |
رقم الانضمام: | edsbas.C999D377 |
قاعدة البيانات: | BASE |
الوصف غير متاح. |