التفاصيل البيبلوغرافية
| العنوان: |
Inflammatory phenotype modulation in the respiratory tract and systemic circulation of e-cigarette users: a pilot study. |
| المؤلفون: |
Sayed, Ibrahim M., Masso-Silva, Jorge A., Mittal, Ankita, Patel, Arjun, Lin, Erica, Moshensky, Alex, Shin, John, Bojanowski, Christine M., Das, Soumita, Akuthota, Praveen, Alexander, Laura E. Crotty |
| المصدر: |
American Journal of Physiology: Lung Cellular & Molecular Physiology; Dec2021, Vol. 321 Issue 6, pL1134-L1146, 13p |
| مصطلحات موضوعية: |
PHENOTYPIC plasticity, ELECTRONIC cigarettes, GROWTH factors, PILOT projects, INFLAMMATION |
| مستخلص: |
Over 40 million people use e-cigarettes worldwide, but the impact of chronic e-cigarette use on health has not been adequately defined. In particular, effects of e-cigarette aerosol inhalation on inflammation and host defenses across the body are not fully understood. We conducted a longitudinal cohort pilot study to explore changes in the inflammatory state and monocyte function of e-cigarette users (n = 20) versus healthy controls (n = 13) and to evaluate effects of e-cigarette use reduction on the same. Saliva, sputum, and blood were obtained from e-cigarette users at baseline and after a 2-wk intervention of decreased e-cigarette use. Overall, across 38 proteins quantified by multiplex, airway samples from e-cigarette users tended to have decreased levels of immunomodulatory proteins relative to healthy controls, whereas levels of cytokines, chemokines, and growth factors in the circulation tended to be elevated. Specifically, e-cigarette users had lower levels of IL-1 receptor antagonist (IL-1Ra) in saliva (P < 0.0001), with higher IL-1Ra and growth-regulated oncogene (GRO) levels in sputum (P < 0.01 and P < 0.05, respectively), and higher levels of both TNFb (P < 0.0001) and VEGF (P < 0.0001) in plasma. Circulating monocytes from e-cigarette users had alterations in their inflammatory phenotype in response to reduced e-cigarette use, with blunted IL-8 and IL-6 release upon challenge with bacterial lipopolysaccharide (P < 0.001 and P < 0.05, respectively), suggesting a decreased ability to appropriately respond to bacterial infection. Based on these findings, chronic inhalation of e-cigarette aerosols alters the inflammatory state of the airways and systemic circulation, raising concern for the development of both inflammatory and infectious diseases in chronic users of e-cigarettes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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