Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart
| العنوان: | Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart |
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| المؤلفون: | Michael N. Sack |
| المصدر: | American Journal of Physiology-Heart and Circulatory Physiology. 301:H2191-H2197 |
| بيانات النشر: | American Physiological Society, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Heart Diseases, SIRT3, Physiology, Lysine, Reviews, Mitochondrion, Biology, Gene Expression Regulation, Enzymologic, Mitochondria, Heart, Cyclophilins, Enzyme activator, Sirtuin 3, Physiology (medical), Animals, Humans, Pressure overload, Myocardium, Acetylation, Enzyme Activation, Metabolic pathway, Biochemistry, Phosphorylation, Energy Metabolism, Reactive Oxygen Species, Cardiology and Cardiovascular Medicine, Protein Processing, Post-Translational, Cyclophilin D |
| الوصف: | Studies to quantify the protein acetylome show that lysine-residue acetylation rivals phosphorylation in prevalence as a posttranslational modification. Interesting, this posttranslational modification is modified by nutrient flux and by redox stress and targets the vast majority of metabolic pathway proteins in the mitochondria. Furthermore, the mitochondrial deacetylase enzyme SIRT3 appears to be regulated by exercise in skeletal muscle and in response to pressure overload in the heart. The alteration of protein lysine residues by acetylation and the enzymes controlling deacetylation are beginning to be explored as important regulatory events in the control of mitochondrial function and homeostasis. This review focuses on the mitochondrial targets of SIRT3 that are functionally implicated in heart biology and pathology and on the direct cardiac consequences of the genetic manipulation of SIRT3. As therapeutic modulators of other SIRT isoforms have been identified, the longer-term objective of our understanding of this biology would be to identify SIRT3 modulators as putative cardiac therapeutic agents. |
| تدمد: | 1522-1539 0363-6135 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dce8b9bb613f4510dc5cb46afbb22Test https://doi.org/10.1152/ajpheart.00199.2011Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d12dce8b9bb613f4510dc5cb46afbb22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221539 03636135 |
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