Hepatic neovascularization after partial portal vein ligation: novel mechanism of chronic regulation of blood flow
| العنوان: | Hepatic neovascularization after partial portal vein ligation: novel mechanism of chronic regulation of blood flow |
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| المؤلفون: | Mark G. Clemens, Yukihiro Yokoyama, Jian X. Zhang, Natalie Sonin, Rajiv Baveja |
| المصدر: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 280:G21-G31 |
| بيانات النشر: | American Physiological Society, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Pathology, Physiology, medicine.medical_treatment, Portal venous pressure, Neovascularization, Physiologic, Corrosion Casting, Microcirculation, Rats, Sprague-Dawley, Neovascularization, Phenylephrine, Hepatic Artery, Physiology (medical), Hypertension, Portal, medicine, Animals, Vasoconstrictor Agents, Ligature, Ligation, L-Lactate Dehydrogenase, Hepatology, Portal Vein, business.industry, Endothelins, Gastroenterology, Alanine Transaminase, Surgical Instruments, medicine.disease, Peptide Fragments, Rats, Surgery, medicine.anatomical_structure, Circulatory system, Microscopy, Electron, Scanning, Portal hypertension, medicine.symptom, business, Blood Flow Velocity, Liver Circulation, Blood vessel |
| الوصف: | The present study was undertaken to investigate hepatic microcirculatory response following partial portal vein ligation (PPVL) in rats. Portal pressure was markedly increased 2–6 wk after PPVL, but no significant reduction in sinusoidal perfusion and hepatocellular injury were detected. However, marked neovascularization was observed in PPVL rats using intravital microscopy and scanning electron microscopy (SEM). Extremely high red blood cell velocity (2,000–4,900 μm /s) was seen in these vessels. Injection of fluorescein sodium via the carotid artery revealed that the neovessels originated from the hepatic arterial vasculature. This was further confirmed by clamping the common hepatic artery and phenylephrine injection from the carotid artery. These vessels maintained sufficient flow after massive sinusoidal shutdown elicited by the portal infusion of endothelin receptor B agonist IRL-1620. SEM also showed extensive neovascularization at the hilum. Additionally, clamping the portal vein decreased sinusoidal perfusion only by 9.5% in PPVL, whereas a 71.2% decrease was observed in sham. These results strongly suggest that the liver maintains its microcirculatory flow by vascular remodeling from the hepatic arterial vasculature following PPVL. |
| تدمد: | 1522-1547 0193-1857 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc01ee0e678866f892fcbbf91c6e98b2Test https://doi.org/10.1152/ajpgi.2001.280.1.g21Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cc01ee0e678866f892fcbbf91c6e98b2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221547 01931857 |
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