Nitric oxide modulates cardiac contractility and oxygen consumption without changing contractile efficiency
| العنوان: | Nitric oxide modulates cardiac contractility and oxygen consumption without changing contractile efficiency |
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| المؤلفون: | Ken Okumura, Atsushi Mikuniya, Hiroyuki Hanada, Tomoyuki Okubo, Nobuyo Shinozaki, Naoyuki Suto |
| المصدر: | American Journal of Physiology-Heart and Circulatory Physiology. 275:H41-H49 |
| بيانات النشر: | American Physiological Society, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | medicine.medical_specialty, Systole, Physiology, chemistry.chemical_element, Hemodynamics, Blood Pressure, Arginine, Nitric Oxide, Oxygen, Ventricular Function, Left, Nitric oxide, Contractility, Electrocardiography, Norepinephrine, chemistry.chemical_compound, Dogs, Oxygen Consumption, Coronary Circulation, Physiology (medical), Internal medicine, medicine, Animals, Fiber Optic Technology, Oximetry, Optical Fibers, omega-N-Methylarginine, biology, Myocardium, Fissipedia, Reproducibility of Results, Heart, biology.organism_classification, Myocardial Contraction, Nitric oxide synthase, Blood pressure, chemistry, Biochemistry, Circulatory system, biology.protein, Cardiology, Cardiology and Cardiovascular Medicine |
| الوصف: | Nitric oxide (NO) affects myocardial contractility and myocardial oxygen consumption (MV˙o 2) in vitro. In α-chloralose-anesthetized dogs instrumented for the measurements of left ventricular (LV) pressure, LV volume using a conductance catheter, coronary blood flow, and coronary venous oxygen saturation (S[Formula: see text]) using a fiber-optic catheter, LV end-systolic pressure-volume relationships (ESPVR) and the relationship between MV˙o 2 and LV pressure-volume area (PVA) were analyzed before and after intravenous infusions of the NO synthase inhibitor N G-monomethyl-l-arginine acetate (l-NMMA; 5 mg/kg, 8 dogs) and the NO substrate l-arginine (600 mg/kg, 7 dogs). l-NMMA increased the slope of the ESPVR ( E max) ( P < 0.05) without changing contractile efficiency indicated by the inverse of the slope of the MV˙o 2-PVA line.l-NMMA also increased unloaded MV˙o 2, indicated by the y-axis intercept of the MV˙o 2-PVA line ( P < 0.05). In contrast,l-arginine decreased E max( P < 0.05) while decreasing MV˙o 2( P < 0.05), and without changing contractile efficiency. The basal oxygen metabolism was not affected byl-NMMA andl-arginine. These data imply that endogenous NO spares MV˙o 2 by reducing oxygen use in excitation-contraction coupling and attenuates cardiac contractility without changing contractile efficiency. |
| تدمد: | 1522-1539 0363-6135 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c8cfd08bcb4924b8304320b545dd1eTest https://doi.org/10.1152/ajpheart.1998.275.1.h41Test |
| رقم الانضمام: | edsair.doi.dedup.....b2c8cfd08bcb4924b8304320b545dd1e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221539 03636135 |
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