Systemic vs. local cytokine and leukocyte responses to unilateral wrist flexion exercise
| العنوان: | Systemic vs. local cytokine and leukocyte responses to unilateral wrist flexion exercise |
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| المؤلفون: | Dan Nemet, Maryann Hill, Dan M. Cooper, Paul J. Mills, Suzi Hong, Michael G. Ziegler |
| المصدر: | Nemet, Dan; Hong, Suzi; Mills, Paul J; Ziegler, Michael G; Hill, Maryann; & Cooper, Dan M. (2002). Systemic vs. local cytokine and leukocyte responses to unilateral wrist flexion exercise.. Journal of applied physiology (Bethesda, Md. : 1985), 93(2), 546-554. doi: 10.1152/japplphysiol.00035.2002. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2zk0f3b1Test |
| بيانات النشر: | American Physiological Society, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Male, Vascular Endothelial Growth Factor A, Wrist Joint, Physiology, Angiogenesis, medicine.medical_treatment, Endothelial Growth Factors, Medical and Health Sciences, Norepinephrine, Heart Rate, Lymphokines, Human Growth Hormone, Vascular Endothelial Growth Factors, Biological Sciences, Cytokine, medicine.anatomical_structure, Hematocrit, Circulatory system, Cytokines, Intercellular Signaling Peptides and Proteins, Female, Fibroblast Growth Factor 2, medicine.symptom, Blood vessel, Adult, medicine.medical_specialty, Epinephrine, white blood cells, Sialoglycoproteins, Physical exercise, Inflammation, Peripheral blood mononuclear cell, Sex Factors, Immune system, single arm, Physiology (medical), medicine, Humans, Lactic Acid, Exercise, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Lymphocyte Subsets, Surgery, Interleukin 1 Receptor Antagonist Protein, inflammation, Immunology, business, Cell Adhesion Molecules, Interleukin-1 |
| الوصف: | We hypothesized that brief exercise of a small muscle group would lead to local rather than systemic alterations in cytokines, peripheral blood mononuclear cells, and mediators of angiogenesis. Fifteen men and eight women (age range 22–36 yr old) performed 10 min of unilateral wrist flexion exercise. Blood was sampled from venous catheters in the resting and exercising arm at baseline, at the end of exercise, and at 10, 30, 60, and 120 min after exercise. Lactate was significantly elevated in the exercising arm (+276 ± 35%; P < 0.0005) with no change in the resting arm. In contrast, increases in both arms were observed for interleukin-6 (+139 ± 51%; P < 0.0005), growth hormone (+1,104 ± 284%; P < 0.003), natural killer cells (+81 ± 9%; P < 0.0005), and lymphocytes expressing CD62L, CD11a, and CD54. There were no significant differences in these increases between the resting and exercising arm. Catecholamines increased in both arms [epinephrine peak increase, +226 ± 36% ( P < 0.001); norepinephrine peak increase, +90 ± 15% ( P < 0.01)]. Fibroblast growth factor-2 initially decreased with exercise in both arms, and this was followed by a rebound increase. Vascular endothelial growth factor demonstrated a small but significant increase in both arms (+124 ± 31%; P < 0.05). Brief, low-intensity exercise leads to a systemic rather than local response of mediators that could be involved in inflammation, repair, or angiogenic adaptation to physical activity. |
| وصف الملف: | application/pdf |
| تدمد: | 1522-1601 8750-7587 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa2464257f92c54cbc07149ba18fae3Test https://doi.org/10.1152/japplphysiol.00035.2002Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6aa2464257f92c54cbc07149ba18fae3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221601 87507587 |
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