Comparative MRI analysis of T2 changes associated with single and repeated bouts of downhill running leading to eccentric-induced muscle damage
| العنوان: | Comparative MRI analysis of T2 changes associated with single and repeated bouts of downhill running leading to eccentric-induced muscle damage |
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| المؤلفون: | David Bendahan, Patrick J. Cozzone, Yann Le Fur, Benoît Giannesini, Tanguy Marqueste |
| المساهمون: | Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU) |
| المصدر: | Journal of Applied Physiology Journal of Applied Physiology, 2008, epub ahead of print. ⟨10.1152/japplphysiol.00738.2007⟩ Journal of Applied Physiology, American Physiological Society, 2008, epub ahead of print. ⟨10.1152/japplphysiol.00738.2007⟩ |
| بيانات النشر: | American Physiological Society, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Downhill running, medicine.medical_specialty, Physiology, Muscle damage, Running, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Isometric Contraction, Physiology (medical), Internal medicine, Delayed onset muscle soreness, Image Processing, Computer-Assisted, Animals, Eccentric, Medicine, Muscle, Skeletal, Creatine Kinase, Electric stimulation, L-Lactate Dehydrogenase, business.industry, Running injuries, 030229 sport sciences, Anatomy, Magnetic Resonance Imaging, Electric Stimulation, Enzymes, Hindlimb, Rats, Sprague dawley, Eccentric exercise, Linear Models, Cardiology, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | Although the exact mechanisms are still unclear, it is commonly acknowledged that acute eccentric exercise alters muscle performance whereas the repetition of successive bouts leads to the disappearance of the deleterious signs. In order to clarify this issue, we measured blood creatine kinase, lactate dehydrogenase activities and proton T2 relaxation time in various leg muscles 72 hours after a single and repeated bouts of exhausting downhill running sessions (-15 degrees ;1.5km/h), elapsed by either 4 or 7-days. After a single exercise bout, T2 and enzyme activities initially increased and recovered rapidly. When exercise bouts were repeated over a short time period (4-days), initial changes did not recover and endurance time throughout additional exercise sessions was significantly reduced. On the contrary, with a longer resting time between exercises (7-days), endurance time of additional running sessions was significantly longer and muscle changes (T2 increase, muscle oedema and enzyme activities changes) slowly and completely reversed. Significant correlations were found between T2 changes and enzymes activities. T2 changes in the soleus and gastrocnemius muscle heads were differently affected by lengthening contractions suggesting a muscle-specificity and indicating that muscle alterations might be linked to different anatomical properties such as fiber pennation angles, typology and/or to the exhausting nature of the downhill running sessions. We documented a "less muscle injury" effect due to the repetition of exercise bouts at a low frequency (i.e. 1 session per week), in accordance with the delayed muscle inflammation. This effect was not observed when the between-exercise resting time was shorter. Key words: eccentric, skeletal muscle, rat, lengthening, functional MR imaging. |
| تدمد: | 1522-1601 8750-7587 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56125e4fa1238cbb506c59f4af9a99cTest https://doi.org/10.1152/japplphysiol.00738.2007Test |
| رقم الانضمام: | edsair.doi.dedup.....c56125e4fa1238cbb506c59f4af9a99c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221601 87507587 |
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