Feasibility of SARS-CoV-2 Surveillance Testing Among Children and Childcare Workers at German Day Care Centers
| العنوان: | Feasibility of SARS-CoV-2 Surveillance Testing Among Children and Childcare Workers at German Day Care Centers |
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| المؤلفون: | Johannes, Forster, Andrea, Streng, Paul, Rudolph, Viktoria, Rücker, Julia, Wallstabe, Sandra, Timme, Franziska, Pietsch, Katrin, Hartmann, Maike, Krauthausen, Julia, Schmidt, Timo, Ludwig, David, Gierszewski, Thomas, Jans, Geraldine, Engels, Benedikt, Weißbrich, Marcel, Romanos, Lars, Dölken, Peter, Heuschmann, Christoph, Härtel, Ildikó, Gágyor, Marc Thilo, Figge, Oliver, Kurzai, Johannes, Liese, Brigitte, Wehner |
| المصدر: | JAMA Network Open |
| بيانات النشر: | American Medical Association (AMA), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Male, Polymerase Chain Reaction, Specimen Handling, COVID-19 Testing, Germany, Humans, Child Care, Child, Saliva, Pandemics, Original Investigation, SARS-CoV-2, Research, Child Health, COVID-19, Child Day Care Centers, General Medicine, Models, Theoretical, Patient Acceptance of Health Care, Online Only, Infectious Diseases, Caregivers, Child, Preschool, Feasibility Studies, Female |
| الوصف: | Key Points Question Is continuous SARS-CoV-2 testing accepted by children, parents, and childcare workers and can it prevent viral spreading in day care centers? Findings In this nonrandomized controlled trial, surveillance testing for SARS-CoV-2 among 954 eligible individuals was well accepted by children, parents, and childcare workers if saliva sampling at home was used. Mathematical modeling based on study and literature data identified biweekly testing of at least 50% of children and childcare workers as minimal requirements to limit secondary infections. Meaning These findings suggest that SARS-CoV-2 surveillance testing is feasible and allows for continued day care attendance for children during the COVID-19 pandemic. This nonrandomized controlled trial investigates the feasibility of SARS-CoV-2 surveillance among children and childcare workers at day care centers in Germany and models the efficacy of surveillance for preventing viral spread. Importance Closure of day care centers has been implemented globally to contain the COVID-19 pandemic but has negative effects on children’s health and psychosocial well-being. Objective To investigate the feasibility of surveillance among children and childcare workers and to model the efficacy of surveillance on viral spread prevention. Design, Setting, and Participants This nonrandomized controlled trial was conducted at 9 day care centers in Wuerzburg, Germany, from October 2020 to March 2021. Participants included children attending day care, childcare workers, and household members. Participating day care centers were assigned to different surveillance modules in a nonrandomized feasibility study. A mathematical model for SARS-CoV-2 spread in day care centers was developed to identify optimal surveillance. Interventions Modules 1, 2, and 3 involved continuous surveillance of asymptomatic children and childcare workers by SARS-CoV-2 polymerase chain reaction testing of either midturbinate nasal swabs twice weekly (module 1) or once weekly (module 2) or self-sampled saliva samples twice weekly (module 3). Module 4 involved symptom-based, on-demand testing of children, childcare workers, and their household members by oropharyngeal swabs. All participants underwent SARS-CoV-2 antibody status testing before and after the sampling period. Questionnaires on attitudes and perception of the pandemic were administered in weeks 1, 6, and 12. Mathematical modeling was used to estimate SARS-CoV-2 spread in day care centers. Main Outcomes and Measures The primary outcomes were acceptance of the respective surveillance protocols (feasibility study) and the estimated number of secondary infections (mathematical modeling). Results Of 954 eligible individuals (772 children and 182 childcare workers), 592 (62%), including 442 children (median [IQR] age, 3 [2-4] years; 214 [48.6%] female) and 150 childcare workers (median [IQR] age, 29 [25-44] years; 129 [90.8%] female) participated in the surveillance. In total, 4755 tests for SARS-CoV-2 detected 2 infections (1 childcare worker and 1 adult household member). Acceptance for continuous surveillance was highest for biweekly saliva testing (150 of 221 eligible individuals [67.9%; 95% CI, 61.5%-73.7%]) compared with biweekly (51 of 117 individuals [43.6%; 95% CI, 35.0%-52.6%]) and weekly (44 of 128 individuals [34.4%; 95% CI, 26.7%-43.0%]) midturbinate swabbing (P |
| تدمد: | 2574-3805 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a747bf2fd238bbddb5e9dab6b6e9e0cTest https://doi.org/10.1001/jamanetworkopen.2021.42057Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5a747bf2fd238bbddb5e9dab6b6e9e0c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25743805 |
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