دورية أكاديمية
International Consensus Definition and Diagnostic Criteria for Generalized Pustular Psoriasis From the International Psoriasis Council
| العنوان: | International Consensus Definition and Diagnostic Criteria for Generalized Pustular Psoriasis From the International Psoriasis Council |
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| المؤلفون: | Choon, Siew Eng, van de Kerkhof, Peter, Gudjonsson, Johann E., de la Cruz, Claudia, Barker, Jonathan, Morita, Akimichi, Romiti, Ricardo, Affandi, Azura Mohd, Asawanonda, Pravit, Burden, Arthur David, Gonzalez, César, Marrakchi, Slaheddine, Mowla, Mohammad Rafiqul, Okubo, Yukari, Oon, Hazel H., Terui, Tadashi, Tsai, Tsen-Fang, Callis-Duffin, Kristina, Fujita, Hideki, Jo, Seong Jin, Merola, Joseph, Mrowietz, Ulrich, Puig, Lluïs, Thaçi, Diamant, Velásquez, Margarita, Augustine, Matthias, El Sayed, Mahira, Navarini, Alexander A., Pink, Andrew, Prinz, Jörg, Turki, Hamida, Magalhães, Renata, Capon, Francesca, Bachelez, Hervé, Aboudourib, Maryem, Adji, Aryani, Alam, Jahangir, Alwakeel, Abdelrahman, Bahloul, Emna, Barboza da Silva, Jaquelini, Barua, Deva Pratim, Chiricozzi, Andrea, Chularojanamontri, Leena, Dadoo, Ahmed, de Rie, Menno, El-Komy, Mohamed, Etemesi, Beatrice, Farhana, Chowdhury, Gisondi, Paolo, Guevara, Bryan |
| المصدر: | JAMA Dermatology ; ISSN 2168-6068 |
| بيانات النشر: | American Medical Association (AMA) |
| سنة النشر: | 2024 |
| الوصف: | Importance Generalized pustular psoriasis (GPP) lacks internationally accepted definitions and diagnostic criteria, impeding timely diagnosis and treatment and hindering cross-regional clinical and epidemiological study comparisons. Objective To develop an international consensus definition and diagnostic criteria for GPP using the modified Delphi method. Evidence Review The rarity of GPP presents a challenge in acquiring comprehensive published clinical data necessary for developing standardized definition and criteria. Instead of relying on a literature search, 43 statements that comprehensively addressed the fundamental aspects of the definitions and diagnostic criteria for GPP were formulated based on expert reviews of 64 challenging GPP cases. These statements were presented to a panel of 33 global GPP experts for voting, discussion, and refinements in 2 virtual consensus meetings. Consensus during voting was defined as at least 80% agreement; the definition and diagnostic criteria were accepted by all panelists after voting and in-depth discussion. Findings In the first and second modified Delphi round, 30 (91%) and 25 (76%) experts participated. In the initial Delphi round, consensus was achieved for 53% of the statements, leading to the approval of 23 statements that were utilized to develop the proposed definitions and diagnostic criteria for GPP. During the second Delphi round, the final definition established was, “Generalized Pustular Psoriasis is a systemic inflammatory disease characterized by cutaneous erythema and macroscopically visible sterile pustules.” It can occur with or without systemic symptoms, other psoriasis types, and laboratory abnormalities. GPP may manifest as an acute form with widespread pustules or a subacute variant with an annular phenotype. The identified essential criterion was, “Macroscopically visible sterile pustules on erythematous base and not restricted to the acral region or within psoriatic plaques.” Conclusions and Relevance The achievement of international ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1001/jamadermatol.2024.0915 |
| الإتاحة: | https://doi.org/10.1001/jamadermatol.2024.0915Test https://jamanetwork.com/journals/jamadermatology/articlepdf/2818462/jamadermatology_choon_2024_cs_240006_1714504342.74789.pdfTest |
| رقم الانضمام: | edsbas.1746A336 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamadermatol.2024.0915 |
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