المؤلفون: Halasa, Natasha, Zambrano, Laura D., Amarin, Justin Z., Stewart, Laura S., Newhams, Margaret M., Levy, Emily R., Shein, Steven L., Carroll, Christopher L., Fitzgerald, Julie C., Michaels, Marian G., Bline, Katherine, Cullimore, Melissa L., Loftis, Laura, Montgomery, Vicki L., Jeyapalan, Asumthia S., Pannaraj, Pia S., Schwarz, Adam J., Cvijanovich, Natalie Z., Zinter, Matt S., Maddux, Aline B., Bembea, Melania M., Irby, Katherine, Zerr, Danielle M., Kuebler, Joseph D., Babbitt, Christopher J., Gaspers, Mary Glas, Nofziger, Ryan A., Kong, Michele, Coates, Bria M., Schuster, Jennifer E., Gertz, Shira J., Mack, Elizabeth H., White, Benjamin R., Harvey, Helen, Hobbs, Charlotte V., Dapul, Heda, Butler, Andrew D., Bradford, Tamara T., Rowan, Courtney M., Wellnitz, Kari, Staat, Mary Allen, Aguiar, Cassyanne L., Hymes, Saul R., Randolph, Adrienne G., Campbell, Angela P., Tomcany, Merry, Michelson, Kelly N., Price, Heather E., Sanders, Ronald C., Dixon, Lexie

المصدر: JAMA Network Open ; volume 6, issue 8, page e2328950 ; ISSN 2574-3805

الوصف: Importance Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections (LRTIs) and infant hospitalization worldwide. Objective To evaluate the characteristics and outcomes of RSV-related critical illness in US infants during peak 2022 RSV transmission. Design, Setting, and Participants This cross-sectional study used a public health prospective surveillance registry in 39 pediatric hospitals across 27 US states. Participants were infants admitted for 24 or more hours between October 17 and December 16, 2022, to a unit providing intensive care due to laboratory-confirmed RSV infection. Exposure Respiratory syncytial virus. Main Outcomes and Measures Data were captured on demographics, clinical characteristics, signs and symptoms, laboratory values, severity measures, and clinical outcomes, including receipt of noninvasive respiratory support, invasive mechanical ventilation, vasopressors or extracorporeal membrane oxygenation, and death. Mixed-effects multivariable log-binomial regression models were used to assess associations between intubation status and demographic factors, gestational age, and underlying conditions, including hospital as a random effect to account for between-site heterogeneity. Results The first 15 to 20 consecutive eligible infants from each site were included for a target sample size of 600. Among the 600 infants, the median (IQR) age was 2.6 (1.4-6.0) months; 361 (60.2%) were male, 169 (28.9%) were born prematurely, and 487 (81.2%) had no underlying medical conditions. Primary reasons for admission included LRTI (594 infants [99.0%]) and apnea or bradycardia (77 infants [12.8%]). Overall, 143 infants (23.8%) received invasive mechanical ventilation (median [IQR], 6.0 [4.0-10.0] days). The highest level of respiratory support for nonintubated infants was high-flow nasal cannula (243 infants [40.5%]), followed by bilevel positive airway pressure (150 infants [25.0%]) and continuous positive airway pressure (52 infants [8.7%]). Infants younger than 3 months, ...

الإتاحة: https://doi.org/10.1001/jamanetworkopen.2023.28950Test
https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2808356/halasa_2023_oi_230837_1691425906.74093.pdfTest

المؤلفون: LaRovere, Kerri L., Poussaint, Tina Y., Young, Cameron C., Newhams, Margaret M., Kucukak, Suden, Irby, Katherine, Kong, Michele, Schwartz, Stephanie P., Walker, Tracie C., Bembea, Melania M., Wellnitz, Kari, Havlin, Kevin M., Cvijanovich, Natalie Z., Hall, Mark W., Fitzgerald, Julie C., Schuster, Jennifer E., Hobbs, Charlotte V., Halasa, Natasha B., Singh, Aalok R., Mack, Elizabeth H., Bradford, Tamara T., Gertz, Shira J., Schwarz, Adam J., Typpo, Katri V., Loftis, Laura L., Giuliano, John S., Horwitz, Steven M., Biagas, Katherine V., Clouser, Katharine N., Rowan, Courtney M., Maddux, Aline B., Soma, Vijaya L., Babbitt, Christopher J., Aguiar, Cassyanne L., Kolmar, Amanda R., Heidemann, Sabrina M., Harvey, Helen, Zambrano, Laura D., Campbell, Angela P., Randolph, Adrienne G., Gaspers, Mary Glas, Sanders, Ronald C, Zinter, Matt S, Pannaraj, Pia S, Port, Emily, Shankman, Sara, Mansour, Rachel, Carroll, Christopher L, McLaughlin, Gwenn E, Espinal, Paula S

المصدر: JAMA Neurology ; volume 80, issue 1, page 91 ; ISSN 2168-6149

الوصف: Importance In 2020 during the COVID-19 pandemic, neurologic involvement was common in children and adolescents hospitalized in the United States for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related complications. Objective To provide an update on the spectrum of SARS-CoV-2–related neurologic involvement among children and adolescents in 2021. Design, Setting, and Participants Case series investigation of patients reported to public health surveillance hospitalized with SARS-CoV-2–related illness between December 15, 2020, and December 31, 2021, in 55 US hospitals in 31 states with follow-up at hospital discharge. A total of 2253 patients were enrolled during the investigation period. Patients suspected of having multisystem inflammatory syndrome in children (MIS-C) who did not meet criteria (n = 85) were excluded. Patients (<21 years) with positive SARS-CoV-2 test results (reverse transcriptase–polymerase chain reaction and/or antibody) meeting criteria for MIS-C or acute COVID-19 were included in the analysis. Exposure SARS-CoV-2 infection. Main Outcomes and Measures Patients with neurologic involvement had acute neurologic signs, symptoms, or diseases on presentation or during hospitalization. Life-threatening neurologic involvement was adjudicated by experts based on clinical and/or neuroradiological features. Type and severity of neurologic involvement, laboratory and imaging data, vaccination status, and hospital discharge outcomes (death or survival with new neurologic deficits). Results Of 2168 patients included (58% male; median age, 10.3 years), 1435 (66%) met criteria for MIS-C, and 476 (22%) had documented neurologic involvement. Patients with neurologic involvement vs without were older (median age, 12 vs 10 years) and more frequently had underlying neurologic disorders (107 of 476 [22%] vs 240 of 1692 [14%]). Among those with neurologic involvement, 42 (9%) developed acute SARS-CoV-2–related life-threatening conditions, including central nervous system ...

الإتاحة: https://doi.org/10.1001/jamaneurol.2022.3881Test
https://jamanetwork.com/journals/jamaneurology/articlepdf/2798383/jamaneurology_larovere_2022_br_220007_1672852464.40076.pdfTest

المؤلفون: Hunt, Elizabeth A., Duval-Arnould, Jordan M., Bembea, Melania M., Raymond, Tia, Calhoun, Aaron, Atkins, Dianne L., Berg, Robert A., Nadkarni, Vinay M., Donnino, Michael, Andersen, Lars W.

المصدر: JAMA Network Open ; volume 1, issue 5, page e182643 ; ISSN 2574-3805

الإتاحة: https://doi.org/10.1001/jamanetworkopen.2018.2643Test
http:///jamanetworkopen/article-pdf/1/5/e182643/17305203/hunt_2018_oi_180131.pdfTest