دورية أكاديمية
An Investigation of Psychosis Subgroups With Prognostic Validation and Exploration of Genetic Underpinnings The PsyCourse Study
| العنوان: | An Investigation of Psychosis Subgroups With Prognostic Validation and Exploration of Genetic Underpinnings The PsyCourse Study |
|---|---|
| المؤلفون: | Dwyer, D., Kalman, J., Budde, M., Kambeitz, J., Ruef, A., Antonucci, L., Kambeitz-Ilankovic, L., Hasan, A., Kondofersky, I., Anderson-Schmidt, H., Gade, K., Reich-Erkelenz, D., Adorjan, K., Senner, F., Schaupp, S., Andlauer, T., Comes, A., Schulte, E., Kloehn-Saghatolislam, F., Gryaznova, A., Hake, M., Bartholdi, K., Flatau-Nagel, L., Reitt, M., Quast, S., Stegmaier, S., Meyers, M., Emons, B., Haussleiter, I., Juckel, G., Nieratschker, V., Dannlowski, U., Yoshida, T., Schmauss, M., Zimmermann, J., Reimer, J., Wiltfang, J., Reininghaus, E., Anghelescu, I., Arolt, V., Baune, B., Konrad, C., Thiel, A., Fallgatter, A., Figge, C., von Hagen, M., Koller, M., Lang, F., Wigand, M., Becker, T., Jaeger, M., Dietrich, D., Scherk, H., Spitzer, C., Folkerts, H., Witt, S., Degenhardt, F., Forstner, A., Rietschel, M., Noethen, M., Mueller, N., Papiol, S., Heilbronner, U., Falkai, P., Schulze, T., Koutsouleris, N. |
| المصدر: | JAMA PSYCHIATRY |
| بيانات النشر: | AMA American Medical Association Amer Medical Assoc |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | psy, edu |
| الوصف: | This cohort study aims to detect psychosis subgroups and examine their illness courses over 1.5 years and their polygenic scores for schizophrenia, bipolar disorder, major depression disorder, and educational achievement. Question Will data-driven clustering using high-dimensional clinical data reveal psychosis subgroups with relevance to prognoses and polygenic risk? Findings In this cohort study including 1223 individuals, in the discovery sample of 765 individuals with predominantly bipolar and schizophrenia diagnoses, 5 subgroups were detected with different clinical signatures, illness trajectories, and genetic scores for educational attainment. Results were validated in a sample of 458 individuals. Meaning New data-driven clustering paired with rigorous validation may offer a means to extend symptom-based psychosis taxonomies toward functional outcomes, genetic markers, and trajectory-based stratifications. Importance Identifying psychosis subgroups could improve clinical and research precision. Research has focused on symptom subgroups, but there is a need to consider a broader clinical spectrum, disentangle illness trajectories, and investigate genetic associations. Objective To detect psychosis subgroups using data-driven methods and examine their illness courses over 1.5 years and polygenic scores for schizophrenia, bipolar disorder, major depression disorder, and educational achievement. Design, Setting, and Participants This ongoing multisite, naturalistic, longitudinal (6-month intervals) cohort study began in January 2012 across 18 sites. Data from a referred sample of 1223 individuals (765 in the discovery sample and 458 in the validation sample) with DSM-IV diagnoses of schizophrenia, bipolar affective disorder (I/II), schizoaffective disorder, schizophreniform disorder, and brief psychotic disorder were collected from secondary and tertiary care sites. Discovery data were extracted in September 2016 and analyzed from November 2016 to January 2018, and prospective validation data were extracted ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/21.11116/0000-0008-C2C1-2Test |
| الإتاحة: | http://hdl.handle.net/21.11116/0000-0008-C2C1-2Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.41456A48 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |