دورية أكاديمية
Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease.
| العنوان: | Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease. |
|---|---|
| المؤلفون: | Schrag, Anette, Bohlken, Jens, Dammertz, Lotte, Teipel, Stefan, Hermann, Wiebke, Akmatov, Manas K, Bätzing, Jörg, Holstiege, Jakob |
| المصدر: | JAMA neurology 80(2), 161–171 (2023). doi:10.1001/jamaneurol.2022.3902 |
| بيانات النشر: | American Medical Association |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, Humans, Male, Aged, Parkinson Disease: diagnosis, Case-Control Studies, Prodromal Symptoms, Restless Legs Syndrome, Anosmia, Risk Factors |
| جغرافية الموضوع: | DE |
| الوصف: | The prodromal phase of Parkinson disease (PD) may last for more than 10 years. Recognition of the spectrum and occurrence of risk factors, comorbidities, and prodromal features of PD can increase understanding of the causes and development of the disease and help identify individuals at risk.To identify the association of a subsequent diagnosis of PD with a range of risk factors and prodromal features, including lifestyle factors, comorbidities, and potential extracerebral manifestations of PD.This was a case-control study using insurance claims of outpatient consultations of patients with German statutory health insurance between January 1, 2011, and December 31, 2020. Included were patients with incident diagnosis of PD without a previous diagnosis of parkinsonism or dementia and controls matched 1:2 for age, sex, region, and earliest year of outpatient encounter.Exposures were selected based on previous systematic reviews, case-control and cohort studies reporting on risk factors, comorbidities, and prodromal features of PD.Previously postulated risk factors and prodromal features of PD, using the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) coding.A total of 138 345 patients with incident PD (mean [SD] age, 75.1 [9.8] years; 73 720 male [53.3%]) and 276 690 matched controls (mean [SD] age, 75.1 (9.8) years; 147 440 male [53.3%]) were identified. Study participants were followed up for a mean (SD) of 6.0 (2.0) years. Consistent with previous reports, risk factors and prodromal features associated with PD included traumatic brain injury, odds ratio (OR), 1.62; 95% CI, 1.36-1.92; alcohol misuse, OR, 1.32; 95% CI, 1.21-1.44; hypertension, OR, 1.29; 95% CI, 1.26-1.31; anosmia, OR, 2.16; 95% CI, 1.59-2.93; and parasomnias (including RBD), OR, 1.62; 95% CI, 1.42-1.84. In addition, there were associations with restless legs syndrome (OR, 4.19; 95% CI, 3.91-4.50), sleep apnea (OR, 1.45; 95% CI, 1.37-1.54), epilepsy (OR, 2.26; 95% CI, 2.07-2.46), migraine ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/2330-9644; info:eu-repo/semantics/altIdentifier/pmid/pmid:36342675; info:eu-repo/semantics/altIdentifier/issn/0003-9942; info:eu-repo/semantics/altIdentifier/issn/2168-6157; info:eu-repo/semantics/altIdentifier/issn/1538-3687; info:eu-repo/semantics/altIdentifier/issn/2168-6149; info:eu-repo/semantics/altIdentifier/issn/0375-8540; https://pub.dzne.de/record/165553Test; https://pub.dzne.de/search?p=id:%22DZNE-2022-01697%22Test |
| الإتاحة: | https://doi.org/10.1001/jamaneurol.2022.3902Test https://pub.dzne.de/record/165553Test https://pub.dzne.de/search?p=id:%22DZNE-2022-01697%22Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.50EB6BF4 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |