دورية أكاديمية
Sleep and Circadian Rhythm Regulation in Early Parkinson Disease
| العنوان: | Sleep and Circadian Rhythm Regulation in Early Parkinson Disease |
|---|---|
| المؤلفون: | Breen, David P., Vuono, Romina, Nawarathna, Upekshani, Fisher, Kate, Shneerson, John M., Reddy, Akhilesh B., Barker, Roger A. |
| بيانات النشر: | American Medical Association |
| سنة النشر: | 2014 |
| المجموعة: | University of Kent: KAR - Kent Academic Repository |
| الوصف: | Importance: Sleep disturbances are recognized as a common nonmotor complaint in Parkinson disease but their etiology is poorly understood. Objective: To define the sleep and circadian phenotype of patients with early-stage Parkinson disease. Design, Setting, and Participants: Initial assessment of sleep characteristics in a large population-representative incident Parkinson disease cohort (N=239) at the University of Cambridge, England, followed by further comprehensive case-control sleep assessments in a subgroup of these patients (n=30) and matched controls (n=15). Main Outcomes and Measures: Sleep diagnoses and sleep architecture based on polysomnography studies, actigraphy assessment, and 24-hour analyses of serum cortisol, melatonin, and peripheral clock gene expression (Bmal1, Per2, and Rev-Erbα). Results: Subjective sleep complaints were present in almost half of newly diagnosed patients and correlated significantly with poorer quality of life. Patients with Parkinson disease exhibited increased sleep latency (P = .04), reduced sleep efficiency (P = .008), and reduced rapid eye movement sleep (P = .02). In addition, there was a sustained elevation of serum cortisol levels, reduced circulating melatonin levels, and altered Bmal1 expression in patients with Parkinson disease compared with controls. Conclusions and Relevance: Sleep dysfunction seen in early Parkinson disease may reflect a more fundamental pathology in the molecular clock underlying circadian rhythms. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://kar.kent.ac.uk/78975/1/Sleep%20and%20circadian%20rhythm%20regulation%20in%20early%20Parkinson%20disease.pdfTest; Breen, David P., Vuono, Romina, Nawarathna, Upekshani, Fisher, Kate, Shneerson, John M., Reddy, Akhilesh B., Barker, Roger A. (2014) Sleep and Circadian Rhythm Regulation in Early Parkinson Disease. JAMA Neurology, 71 (5). pp. 589-595. ISSN 2168-6149. (doi:10.1001/jamaneurol.2014.65 ) (KAR id:78975 ) |
| DOI: | 10.1001/jamaneurol.2014.65 |
| الإتاحة: | https://doi.org/10.1001/jamaneurol.2014.65Test https://kar.kent.ac.uk/78975Test/ https://kar.kent.ac.uk/78975/1/Sleep%20and%20circadian%20rhythm%20regulation%20in%20early%20Parkinson%20disease.pdfTest |
| رقم الانضمام: | edsbas.A50896C6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamaneurol.2014.65 |
|---|