دورية أكاديمية
Prognostic Factors of Paraneoplastic Pemphigus.
| العنوان: | Prognostic Factors of Paraneoplastic Pemphigus. |
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| المؤلفون: | Leger, Sandy, Picard, Damien, Ingen-Housz-Oro, Saskia, Arnault, Jean-Philippe, Aubin, François, Carsuzaa, Francis, Chaumentin, Gilles, Chevrant-Breton, Jacqueline, Chosidow, Olivier, Crickx, Béatrice, d'Incan, Michel, Dandurand, Michel, Debarbieux, Stéphane, Delaporte, Emmanuel, Dereure, Olivier, Doutre, Marie-Sylvie, Guillet, Gérard, Jullien, Denis, Kupfer, Ingrid, Lacour, Jean-Philippe, Leonard, Fabienne, Lok, Catherine, Machet, Laurent, Martin, Ludovic, Paul, Carle F, Pignon, Jean-Michel, Robert, Caroline, Thomas, Luc, Weiller, Pierre-Jean, Ferranti, Vincent, Gilbert, Danièle, Courville, Philippe, Houivet, Estelle, Benichou, Jacques, Joly, Pascal |
| المساهمون: | Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Littoral, Environnement, Télédétection, Géomatique (LETG-Angers), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Université de Nantes (UN), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Service de Dermatologie, Hôtel-Dieu, Hôpital Edouard Herriot CHU - HCL, Hospices Civils de Lyon (HCL), Department of Dermatology, Université d'Angers (UA), Service de dermatologie, Département de médecine oncologique Gustave Roussy, Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Service de Dermatologie, Centre Hospitalier Sud, Hospices Civils, Lyon, Protéines de défense des réponses immune et inflammatoire : identification, régulation et rôles physiopathologiques, Unité de Biostatistiques CHU Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU) |
| المصدر: | ISSN: 0003-987X ; Archives of Dermatology -Chicago- ; https://hal.science/hal-00727669Test ; Archives of Dermatology -Chicago-, 2012, pp.1-8. ⟨10.1001/archdermatol.2012.1830⟩. |
| بيانات النشر: | HAL CCSD American Medical Association |
| سنة النشر: | 2012 |
| المجموعة: | Archive Ouverte de l'Université Rennes (HAL) |
| مصطلحات موضوعية: | [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; OBJECTIVE To identify the prognostic factors of overall survival in a series of patients with paraneoplastic pemphigus (PNP). DESIGN Multicenter retrospective cohort study. SETTING Twenty-seven dermatology departments in France. PATIENTS A total of 53 patients (31 men and 22 women; median age, 59 years; age range, 30-88 years) were diagnosed as having PNP between 1992 and 2010. MAIN OUTCOME MEASURES Overall Kaplan-Meier survival rates were estimated, and features associated with survival were assessed using univariate (log-rank test) and multivariate (Cox regression) analyses. RESULTS The study included 53 patients with PNP. Thirty-six patients (68%) died during the study. The 1-, 3-, and 5-year overall survival rates were 49%, 41%, and 38%, respectively. The main causes of death were infections (n = 21) and evolution of neoplasia (n = 6). In univariate analysis, the main detrimental prognostic factors identified were erythema multiforme-like skin lesions (P = .05) and histologic keratinocyte necrosis (P = .03). None of the 5 patients with Castleman disease died during the study. After adjustment for age and sex in multivariate analysis, erythema multiforme-like skin lesions remained predictive of fatal outcome, with a 2-fold increase in death rate (hazard ratio [HR], 2.3; 95% CI, 1.05-5.03; P = .04). The prognosis of patients with PNP was even poorer when erythema multiforme-like skin lesions were associated with severe skin or mucosal involvement at presentation (HR of death, 3.0; 95% CI, 1.01-8.92; P = .049). CONCLUSION Patients with PNP with erythema multiforme-like skin lesions and histologic keratinocyte necrosis, especially when associated with extensive lesions at presentation, are likely to have a more severe and rapid fatal outcome and should be managed very carefully. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/22801794; hal-00727669; https://hal.science/hal-00727669Test; PUBMED: 22801794 |
| DOI: | 10.1001/archdermatol.2012.1830 |
| الإتاحة: | https://doi.org/10.1001/archdermatol.2012.1830Test https://hal.science/hal-00727669Test |
| رقم الانضمام: | edsbas.D19923AB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/archdermatol.2012.1830 |
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