دورية أكاديمية
Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci.
| العنوان: | Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. |
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| المؤلفون: | Jones, GT, Tromp, G, Kuivaniemi, H, Gretarsdottir, S, Baas, AF, Giusti, B, Strauss, E, Van 't Hof, FN, Webb, T, Erdman, R, Ritchie, MD, Humphries, SE, Hamby, SE, Goodall, AH, Nelson, CP, Sakalihasan, N, Courtois, A, Ferrell, RE, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Lipovich, L, Eicher, JD, Johnson, AD, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E, Björkegren, JL, Drolet, AM, Verhoeven, E, Zeebregts, CJ, Geelkerken, RH, Van Sambeek, MR, Van Sterkenburg, SM, De Vries, JP, Stefansson, K, Thompson, JR, Elmore, JR, De Bakker, PI, Deloukas, P, Sayers, RD, Harrison, S, Van Rij, AM, Samani, NJ, Bown, MJ, Verma, A, Pendergrass, S, Kullo, IJ, Ye, Z, Peissig, PL, Gottesman, O, Verma, SS, Malinowski, J, Rasmussen-Torvik, LJ, Borthwick, K, Smelser, DT, Crosslin, DR, De Andrade, M, Ryer, EJ, McCarty, CA, Bottinger, EP, Pacheco, JA, Crawford, DC, Carrell, DS, Gerhard, GS, Franklin, DP, Carey, DJ, Phillips, VL, Williams, MJ, Wei, W, Blair, R, Hill, AA, Vasudevan, TM, Lewis, DR, Thomson, IA, Krysa, J, Hill, GB, Roake, J, Merriman, TR, Oszkinis, G, Galora, S, Saracini, C, Abbate, R, Pulli, R, Pratesi, C, Saratzis, A, Verissimo, A, Bumpstead, SJ, Badger, SA, Clough, RE, Cockerill, GW, Hafez, H, Scott, DJ, Futers, TS, Romaine, SP, Bridge, K, Griffin, KJ, Bailey, MA, Smith, A, Thompson, MM, Van Bockxmeer, F, Matthiasson, SE, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, JD, Teijink, JA, Wijmenga, C, De Graaf, J, Kiemeney, LA, Lindholt, JS, Hughes, AE, Bradley, DT, Stirrups, K, Golledge, J, Norman, PE, Powell, JT |
| المصدر: | 353 ; 341 |
| بيانات النشر: | American Heart Association |
| سنة النشر: | 2016 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Hematology, Peripheral Vascular Disease, Cardiovascular System & Cardiology, aortic aneurysm, abdominal, computational biology, genetics, genome-wide association study, matrix metalloproteinases, meta-analysis, CORONARY-ARTERY-DISEASE, DENSITY-LIPOPROTEIN CHOLESTEROL, ELECTRONIC MEDICAL-RECORDS, CANDIDATE GENE ASSOCIATION, RECEPTOR-RELATED PROTEIN-1, HUMAN PREFRONTAL CORTEX, C-REACTIVE PROTEIN, SUSCEPTIBILITY LOCI, SEQUENCE VARIANT, TRANSCRIPTION FACTORS, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Humans, Cardiovascular System & Hematology, 1103 Clinical Sciences, 1102 Cardiovascular Medicine And Haematology |
| جغرافية الموضوع: | United States |
| الوصف: | RATIONALE: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. OBJECTIVE: To identify additional AAA risk loci using data from all available genome-wide association studies (GWAS). METHODS AND RESULTS: Through a meta-analysis of 6 GWAS datasets and a validation study totalling 10,204 cases and 107,766 controls we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches we observed no new associations between the lead AAA SNPs and coronary artery disease, blood pressure, lipids or diabetes. Network analyses identified ERG, IL6R and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. CONCLUSIONS: The 4 new risk loci for AAA appear to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1524-4571 |
| العلاقة: | Circulation Research; http://hdl.handle.net/10044/1/43361Test; https://dx.doi.org/10.1161/CIRCRESAHA.116.308765Test |
| DOI: | 10.1161/CIRCRESAHA.116.308765 |
| الإتاحة: | https://doi.org/10.1161/CIRCRESAHA.116.308765Test http://hdl.handle.net/10044/1/43361Test |
| حقوق: | © 2016 Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0Test/), which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited. |
| رقم الانضمام: | edsbas.DDBE6611 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15244571 |
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| DOI: | 10.1161/CIRCRESAHA.116.308765 |