المؤلفون: Lauri C., Tamminga M., Glaudemans A. W. J. M., Juarez Orozco L. E., Erba P. A., Jutte P. C., Lipsky B. A., IJzerman M. J., Signore A., Slart R. H. J. A.

المساهمون: Lauri, C., Tamminga, M., Glaudemans, A. W. J. M., Juarez Orozco, L. E., Erba, P. A., Jutte, P. C., Lipsky, B. A., Ijzerman, M. J., Signore, A., Slart, R. H. J. A.

مصطلحات موضوعية: bone and bone, databases, factual, diabetic foot, human, osteomyeliti, sensitivity and specificity, leukocyte, magnetic resonance imaging, positron-emission tomography, radionuclide imaging

الوصف: OBJECTIVE Diagnosing bone infection in the diabetic foot is challenging and often requires several diagnostic procedures, including advanced imaging. We compared the diagnostic performances of MRI, radiolabeled white blood cell (WBC) scintigraphy (either with 99mTc-hexamethylpropyleneamineoxime [HMPAO] or 111In-oxine), and [18F]fluorodeoxyglucose positron emission tomography (18F-FDG-PET)/ computed tomography. RESEARCH DESIGN AND METHODS We searchedMedline andEmbase as of August 2016 for studies of diagnostic tests on patients known or suspected to have diabetes and a foot infection. We performed a systematic review using criteria recommended by the Cochrane Review of a database that included prospective and retrospective diagnostic studies performed on patients with diabetes in whom there was a clinical suspicion of osteomyelitis of the foot. The preferred reference standard was bone biopsy and subsequent pathological (or microbiological) examination. RESULTS Our review found 6,649 articles; 3,894 in Medline and 2,755 in Embase. A total of 27 full articles and 2 posters was selected for inclusion in the analysis. The performance characteristics for the 18F-FDG-PET were: sensitivity, 89%; specificity, 92%; diagnostic odds ratio (DOR), 95; positive likelihood ratio (LR), 11; and negative LR, 0.11. For WBC scan with 111In-oxine, the values were: sensitivity, 92%; specificity, 75%; DOR, 34; positive LR, 3.6; and negative LR, 0.1. For WBC scan with 99mTc-HMPAO, the values were: sensitivity, 91%; specificity, 92%; DOR, 118; positive LR, 12; and negative LR, 0.1. Finally, forMRI, the valueswere: sensitivity, 93%; specificity, 75%; DOR, 37; positive LR, 3.66, and negative LR, 0.10. CONCLUSIONS The various modalities have similar sensitivity, but 18F-FDG-PET and 99mTc-HMPAO-labeled WBC scintigraphy offer the highest specificity. Larger prospective studies with a direct comparison among the different imaging techniques are required.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28733376; info:eu-repo/semantics/altIdentifier/wos/WOS:000406014200029; volume:40; issue:8; firstpage:1111; lastpage:1120; numberofpages:10; journal:DIABETES CARE; http://hdl.handle.net/11573/1414200Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85028043823

الإتاحة: https://doi.org/10.2337/dc17-0532Test
http://hdl.handle.net/11573/1414200Test

المؤلفون: Benjamin A. Lipsky, Menno Tamminga, Alberto Signore, Andor W. J. M. Glaudemans, Paola Anna Erba, Maarten Joost IJzerman, Paul C Jutte, Riemer H. J. A. Slart, Luis Juarez Orozco, Chiara Lauri

المساهمون: Lauri, C, Tamminga, M, Glaudemans, A, Juarez Orozco, L, Erba, P, Jutte, P, Lipsky, B, Ijzerman, M, Signore, A, Slart, R, Health Technology & Services Research, Biomedical Photonic Imaging

المصدر: Diabetes care, 40(8), 1111-1120. American Diabetes Association Inc.

مصطلحات موضوعية: Databases, Factual, IMPACT, Endocrinology, Diabetes and Metabolism, Scintigraphy, Likelihood ratios in diagnostic testing, 030218 nuclear medicine & medical imaging, PRIOR MYOCARDIAL-INFARCTION, MELLITUS, Endocrinology, 0302 clinical medicine, Leukocytes, Prospective cohort study, RISK, medicine.diagnostic_test, Osteomyelitis, Magnetic Resonance Imaging, Diabetic Foot, Diabetes and Metabolism, CARDIOVASCULAR-DISEASE, Positron emission tomography, factual, Radiology, INTERVENTION, Bone and Bone, Human, medicine.medical_specialty, databases, 030209 endocrinology & metabolism, bone and bones, databases, factual, diabetic foot, humans, osteomyelitis, sensitivity and specificity, leukocytes, magnetic resonance imaging, positron-emission tomography, radionuclide imaging, Sensitivity and Specificity, Bone and Bones, 03 medical and health sciences, Internal Medicine, Advanced and Specialized Nursing, medicine, Osteomyeliti, Humans, CORONARY-HEART-DISEASE, Radionuclide Imaging, business.industry, MORTALITY, Magnetic resonance imaging, Leukocyte, medicine.disease, RANDOMIZED-TRIALS, 22/4 OA procedure, Diabetic foot, Positron-Emission Tomography, Diagnostic odds ratio, FOLLOW-UP, business

الوصف: OBJECTIVE Diagnosing bone infection in the diabetic foot is challenging and often requires several diagnostic procedures, including advanced imaging. We compared the diagnostic performances of MRI, radiolabeled white blood cell (WBC) scintigraphy (either with 99mTc-hexamethylpropyleneamineoxime [HMPAO] or 111In-oxine), and [18F]fluorodeoxyglucose positron emission tomography (18F-FDG–PET)/computed tomography. RESEARCH DESIGN AND METHODS We searched Medline and Embase as of August 2016 for studies of diagnostic tests on patients known or suspected to have diabetes and a foot infection. We performed a systematic review using criteria recommended by the Cochrane Review of a database that included prospective and retrospective diagnostic studies performed on patients with diabetes in whom there was a clinical suspicion of osteomyelitis of the foot. The preferred reference standard was bone biopsy and subsequent pathological (or microbiological) examination. RESULTS Our review found 6,649 articles; 3,894 in Medline and 2,755 in Embase. A total of 27 full articles and 2 posters was selected for inclusion in the analysis. The performance characteristics for the 18F-FDG–PET were: sensitivity, 89%; specificity, 92%; diagnostic odds ratio (DOR), 95; positive likelihood ratio (LR), 11; and negative LR, 0.11. For WBC scan with 111In-oxine, the values were: sensitivity, 92%; specificity, 75%; DOR, 34; positive LR, 3.6; and negative LR, 0.1. For WBC scan with 99mTc-HMPAO, the values were: sensitivity, 91%; specificity, 92%; DOR, 118; positive LR, 12; and negative LR, 0.1. Finally, for MRI, the values were: sensitivity, 93%; specificity, 75%; DOR, 37; positive LR, 3.66, and negative LR, 0.10. CONCLUSIONS The various modalities have similar sensitivity, but 18F-FDG–PET and 99mTc-HMPAO–labeled WBC scintigraphy offer the highest specificity. Larger prospective studies with a direct comparison among the different imaging techniques are required.

وصف الملف: STAMPA; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eebcda8380243ef1997f7bf25169e79Test
https://hdl.handle.net/10281/425118Test

مستخلص: OBJECTIVE Diagnosing bone infection in the diabetic foot is challenging and often requires several diagnostic procedures, including advanced imaging. We compared the diagnostic performances of MRI, radiolabeled white blood cell (WBC) scintigraphy (either with 99mTc-hexamethylpropyleneamineoxime [HMPAO] or 111In-oxine), and [18F]fluorodeoxyglucose positron emission tomography (18F-FDG-PET)/ computed tomography. RESEARCH DESIGN AND METHODS We searchedMedline andEmbase as of August 2016 for studies of diagnostic tests on patients known or suspected to have diabetes and a foot infection. We performed a systematic review using criteria recommended by the Cochrane Review of a database that included prospective and retrospective diagnostic studies performed on patients with diabetes in whom there was a clinical suspicion of osteomyelitis of the foot. The preferred reference standard was bone biopsy and subsequent pathological (or microbiological) examination. RESULTS Our review found 6,649 articles; 3,894 in Medline and 2,755 in Embase. A total of 27 full articles and 2 posters was selected for inclusion in the analysis. The performance characteristics for the 18F-FDG-PET were: sensitivity, 89%; specificity, 92%; diagnostic odds ratio (DOR), 95; positive likelihood ratio (LR), 11; and negative LR, 0.11. For WBC scan with 111In-oxine, the values were: sensitivity, 92%; specificity, 75%; DOR, 34; positive LR, 3.6; and negative LR, 0.1. For WBC scan with 99mTc-HMPAO, the values were: sensitivity, 91%; specificity, 92%; DOR, 118; positive LR, 12; and negative LR, 0.1. Finally, forMRI, the valueswere: sensitivity, 93%; specificity, 75%; DOR, 37; positive LR, 3.66, and negative LR, 0.10. CONCLUSIONS The various modalities have similar sensitivity, but 18F-FDG-PET and 99mTc-HMPAO-labeled WBC scintigraphy offer the highest specificity. Larger prospective studies with a direct comparison among the different imaging techniques are required.

مصطلحات الفهرس: Bone and Bone, Databases, Factual, Diabetic Foot, Human, Leukocyte, Magnetic Resonance Imaging, Osteomyeliti, Positron-Emission Tomography, Radionuclide Imaging, Sensitivity and Specificity, info:eu-repo/semantics/article

URL: https://hdl.handle.net/10281/425118Test
info:eu-repo/semantics/altIdentifier/pmid/28733376
info:eu-repo/semantics/altIdentifier/wos/WOS:000406014200029
volume:40
issue:8
firstpage:1111
lastpage:1120
numberofpages:10
journal:DIABETES CARE