مورد إلكتروني
Detection of osteomyelitis in the diabetic foot by imaging techniques: A systematic review and meta-analysis comparing mri, white blood cell scintigraphy, and FDG-PET
| العنوان: | Detection of osteomyelitis in the diabetic foot by imaging techniques: A systematic review and meta-analysis comparing mri, white blood cell scintigraphy, and FDG-PET |
|---|---|
| بيانات النشر: | American Diabetes Association Inc. country:US 2017 |
| تفاصيل مُضافة: | Lauri, C Tamminga, M Glaudemans, A Juarez Orozco, L Erba, P Jutte, P Lipsky, B Ijzerman, M Signore, A Slart, R Lauri C. Tamminga M. Glaudemans A. W. J. M. Juarez Orozco L. E. Erba P. A. Jutte P. C. Lipsky B. A. IJzerman M. J. Signore A. Slart R. H. J. A. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | OBJECTIVE Diagnosing bone infection in the diabetic foot is challenging and often requires several diagnostic procedures, including advanced imaging. We compared the diagnostic performances of MRI, radiolabeled white blood cell (WBC) scintigraphy (either with 99mTc-hexamethylpropyleneamineoxime [HMPAO] or 111In-oxine), and [18F]fluorodeoxyglucose positron emission tomography (18F-FDG-PET)/ computed tomography. RESEARCH DESIGN AND METHODS We searchedMedline andEmbase as of August 2016 for studies of diagnostic tests on patients known or suspected to have diabetes and a foot infection. We performed a systematic review using criteria recommended by the Cochrane Review of a database that included prospective and retrospective diagnostic studies performed on patients with diabetes in whom there was a clinical suspicion of osteomyelitis of the foot. The preferred reference standard was bone biopsy and subsequent pathological (or microbiological) examination. RESULTS Our review found 6,649 articles; 3,894 in Medline and 2,755 in Embase. A total of 27 full articles and 2 posters was selected for inclusion in the analysis. The performance characteristics for the 18F-FDG-PET were: sensitivity, 89%; specificity, 92%; diagnostic odds ratio (DOR), 95; positive likelihood ratio (LR), 11; and negative LR, 0.11. For WBC scan with 111In-oxine, the values were: sensitivity, 92%; specificity, 75%; DOR, 34; positive LR, 3.6; and negative LR, 0.1. For WBC scan with 99mTc-HMPAO, the values were: sensitivity, 91%; specificity, 92%; DOR, 118; positive LR, 12; and negative LR, 0.1. Finally, forMRI, the valueswere: sensitivity, 93%; specificity, 75%; DOR, 37; positive LR, 3.66, and negative LR, 0.10. CONCLUSIONS The various modalities have similar sensitivity, but 18F-FDG-PET and 99mTc-HMPAO-labeled WBC scintigraphy offer the highest specificity. Larger prospective studies with a direct comparison among the different imaging techniques are required. |
| مصطلحات الفهرس: | Bone and Bone, Databases, Factual, Diabetic Foot, Human, Leukocyte, Magnetic Resonance Imaging, Osteomyeliti, Positron-Emission Tomography, Radionuclide Imaging, Sensitivity and Specificity, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/28733376 info:eu-repo/semantics/altIdentifier/wos/WOS:000406014200029 volume:40 issue:8 firstpage:1111 lastpage:1120 numberofpages:10 journal:DIABETES CARE |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | STAMPA English |
| أرقام أخرى: | ITBAO oai:boa.unimib.it:10281/425118 10.2337/dc17-0532 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85028043823 1383765966 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1383765966 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |