Noninvasive Detection of Cardiac Sympathetic Nervous Dysfunction in Diabetic Patients Using [123I]Metaiodobenzylguanidine
| العنوان: | Noninvasive Detection of Cardiac Sympathetic Nervous Dysfunction in Diabetic Patients Using [123I]Metaiodobenzylguanidine |
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| المؤلفون: | Matti Uusitupa, Esko Vanninen, Jyrki T. Kuikka, Juha Mustonen, Esko Länsimies, Matti Mäntysaari, Kari U. O. Tahvanainen |
| المصدر: | Diabetes. 41:1069-1075 |
| بيانات النشر: | American Diabetes Association, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Sympathetic Nervous System, Endocrinology, Diabetes and Metabolism, Autonomic Nervous System, 3-Iodobenzylguanidine, Mibg uptake, Iodine Radioisotopes, Catecholamines, Diabetic Neuropathies, Heart Rate, Isometric Contraction, Diabetes mellitus, Internal medicine, Diabetes Mellitus, Internal Medicine, medicine, Humans, Iodobenzenes, 123i mibg, business.industry, Myocardium, Middle Aged, medicine.disease, Control subjects, Coronary heart disease, Endocrinology, Injections, Intravenous, Circulatory system, Sympatholytics, cardiovascular system, Cardiology, Autonomic neuropathy, business |
| الوصف: | The association between clinical autonomic dysfunction and myocardial MIBG accumulation was investigated. The study groups comprised 6 male diabetic patients with autonomic neuropathy (ANP+ group), 6 male diabetic patients without autonomic neuropathy (ANP- group), and 6 male nondiabetic control subjects. The mean age was comparable in all groups, and the subjects had no evidence of coronary heart disease. Reduced heart-rate variation in a deep-breathing test was used as a criterion for autonomic neuropathy. Immediately after injection, the peak net influx rate of MIBG to myocardium was significantly (P < 0.05) reduced in both diabetic groups. At 6 hr after MIBG injection, the MIBG uptake of the myocardium was significantly (P < 0.05) smaller in the ANP+ group than in the control group. In the ANP- group, the MIBG uptake of the myocardium was between that of the ANP+ group and that of the control group. Our data show that reduced myocardial MIBG accumulation is associated with autonomic dysfunction in diabetic patients, but it can occur to a lesser extent also in diabetic patients without apparent autonomic neuropathy. The measurement of the myocardial MIBG accumulation is a promising new method to detect cardiac sympathetic nervous dysfunction in diabetic patients. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75424455a8f7877d7b136c84910faa97Test https://doi.org/10.2337/diab.41.9.1069Test |
| رقم الانضمام: | edsair.doi.dedup.....75424455a8f7877d7b136c84910faa97 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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