التفاصيل البيبلوغرافية
| العنوان: |
Checks and Balances-The Limits of β-Cell Endurance to ER Stress. |
| المؤلفون: |
Eizirik, Decio L., de Brachène, Alexandra Coomans, Coomans de Brachène, Alexandra |
| المصدر: |
Diabetes; Jun2017, Vol. 66 Issue 6, p1467-1469, 3p, 1 Diagram |
| مصطلحات موضوعية: |
SMALL interfering RNA, B cells, PHYSIOLOGICAL stress, TYPE 2 diabetes, INSULIN, GENES, CYTOPLASM, ISLANDS of Langerhans, RESEARCH funding |
| مستخلص: |
The article discusses the study by Z. Pappalardo and colleagues on small interfering RNA (siRNA) to determine the limits of ß-cell's endurance in severe stress. The study reportedly involved performance of whole-genome RNAi screen to identify genes that affect insulin transcription. The results revealed a novel UPR regulator in pancreatic ß-cells which is a candidate gene for type 2 diabetes. |
| قاعدة البيانات: |
Complementary Index |
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