التفاصيل البيبلوغرافية
| العنوان: |
Effect of Rimonabant on Glycemic Control in Insulin-Treated Type 2 Diabetes: The ARPEGGIO Trial. |
| المؤلفون: |
Hollander, Priscilla A., Amod, Aslam, Litwak, Leon E., Chaudhari, Umesh |
| المصدر: |
Diabetes Care; Mar2010, Vol. 33 Issue 3, p605-607, 3p, 1 Graph |
| مصطلحات موضوعية: |
GLYCEMIC index, INSULIN, TYPE 2 diabetes, THERAPEUTICS, CLINICAL trials, BODY weight |
| مستخلص: |
OBJECTIVE-- To examine the efficacy and safety of rimonabant, a selective cannabinoid receptor type-1 antagonist, in patients with type 2 diabetes receiving insulin monotherapy. RESEARCH DESIGN AND METHODS-- Patients (n = 368; A1C >-7%) were randomized to 20 rag/day rimonabant or placebo in this 48-week, double-blind, placebo-controlled multicenter trial. Change in baseline A1C to week 48 (primary outcome) and changes in body weight, waist circumference, and lipid levels (secondary outcomes) were assessed. RESULTS-- Rimonabant significantly reduced baseline A1C versus placebo (-0.89 vs. -0.24%; P < 0.0001), and significantly greater improvements were observed in cardiometabolic risk factors. More rimonabant patients achieved >10% reduction in mean total daily insulin dose versus placebo (P = 0.0012), and fewer required rescue medication (P < 0.0001). Hypoglycemia, nausea, dizziness, anxiety, and depression were more frequent with rimonabant. CONCLUSIONS-- Rimonabant improved glycemic control and cardiometabolic risk factors in patients with type 2 diabetes receiving insulin. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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