Leptin and Leptin Receptor Gene Polymorphisms and Changes in Glucose Homeostasis in Response to Regular Exercise in Nondiabetic Individuals
| العنوان: | Leptin and Leptin Receptor Gene Polymorphisms and Changes in Glucose Homeostasis in Response to Regular Exercise in Nondiabetic Individuals |
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| المؤلفون: | Jack H. Wilmore, S. John Weisnagel, Normand G. Boulé, Tuomo Rankinen, Timo A. Lakka, Hanna Maaria Lakka, D. C. Rao, Richard N. Bergman, Yvon C. Chagnon, Olavi Ukkola, James S. Skinner, Treva Rice, Arthur S. Leon, Claude Bouchard |
| المصدر: | Diabetes. 53:1603-1608 |
| بيانات النشر: | American Diabetes Association, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | medicine.medical_specialty, Leptin receptor, Endocrinology, Diabetes and Metabolism, Leptin, Insulin, medicine.medical_treatment, education, Carbohydrate metabolism, Biology, medicine.disease, Endocrinology, Insulin resistance, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Glucose homeostasis, Allele, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | We recently reported that a genomic region close to the leptin locus was linked to fasting insulin response to exercise training in nondiabetic white subjects. We tested the hypothesis that common exonic variants in the leptin (LEP) and leptin receptor (LEPR) genes modify the effects of regular physical activity on glucose homeostasis in nondiabetic whites (n = 397) and blacks (n = 143). In whites, exercise increased insulin sensitivity index (P = 0.041) and disposition index (P = 0.046) in the LEPR 109R allele carriers but not in the K109K homozygotes, increased glucose disappearance index more in the R109R homozygotes than in the K109 allele carriers (P = 0.039), and decreased fasting glucose only in the 109R allele carriers (P = 0.018). We also found an interaction between the LEP A19G and LEPR K109R polymorphisms on the change in fasting insulin in whites (P = 0.010). The association between the LEP A19G polymorphism and the change in insulin was evident only in the LEPR 109R carriers (P = 0.019). The decrease in insulin was strongest in the LEP A19A homozygotes who carried the LEPR 109R allele. Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::698a7b14acbeaa1eb8e90ba6ca50f8faTest https://doi.org/10.2337/diabetes.53.6.1603Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........698a7b14acbeaa1eb8e90ba6ca50f8fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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