Alterations in Glucose Metabolism During Menstrual Cycle in Women With IDDM
| العنوان: | Alterations in Glucose Metabolism During Menstrual Cycle in Women With IDDM |
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| المؤلفون: | Michael P. Diamond, Barbara Widom, Donald C. Simonson |
| المصدر: | Diabetes Care. 15:213-220 |
| بيانات النشر: | American Diabetes Association, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Adult, Blood Glucose, endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Glucose uptake, Luteal Phase, Luteal phase, Insulin Infusion Systems, Internal medicine, Follicular phase, Internal Medicine, medicine, Humans, Menstrual Cycle, Testosterone, Menstrual cycle, media_common, Advanced and Specialized Nursing, business.industry, Glucose clamp technique, Prolactin, Diabetes Mellitus, Type 1, Endocrinology, Follicular Phase, Hyperglycemia, Glucose Clamp Technique, Female, Luteinizing hormone, business |
| الوصف: | Objective — To examine the hormonal mechanisms underlying the variability in glycemic control during the different phases of the menstrual cycle in women with insulin-dependent diabetes mellitus (IDDM). Research Design And Methods — Hyperglycemic (11.7 ± 0.1 mM), hyperinsulinemic (24 ± 3 mU/L) clamp studies were performed in 16 women with IDDM during the follicular (day 8 ± 1) and luteal (day 23 ± 1) phases of the menstrual cycle. Seven of the patients (group 1) experienced worsening glucose control during the luteal phase, whereas nine patients (group 2) did not. Results — In group 1, glucose metabolism fell from 30.2 ± 3.8 μmol·kg−1·min−1 during the follicular phase to 24.5 ± 2.0 μmol·kg−1·min−1 during the luteal phase (P = 0.09), whereas in group 2 it increased from 18.5 ± 1.2 to 23.2 ± 2.3 μmol·kg−1·min−1 (P = 0.03). The decrease in glucose metabolism during the luteal phase in patients in group 1 was associated with a significant rise in the serum estradiol levels from the follicular to luteal phase (164 ± 39 vs. 352 ± 59 pM, P = 0.006), whereas this rise was not observed in group 2 (334 ± 156 vs. 423 ± 74 pM, NS). Changes in other reproductive hormones (progesterone, testosterone, dihydrotestosterone, androstenedione, luteinizing hormone, follicular-stimulating hormone, or prolactin) were not related to the differences in glucose uptake in the two groups. Conclusions — 1) Marked heterogeneity in glucose metabolism is seen throughout the menstrual cycle in women with IDDM, 2) a subgroup of patients exhibits worsening premenstrual hyperglycemia and a decline in insulin sensitivity during the luteal phase, and 3) the deterioration in glucose uptake in this subgroup was associated with a greater increment in estradiol levels from the follicular to the luteal phase. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b188f0abcae23cb34c30c851547b1b9Test https://doi.org/10.2337/diacare.15.2.213Test |
| رقم الانضمام: | edsair.doi.dedup.....2b188f0abcae23cb34c30c851547b1b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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