دورية أكاديمية
Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies
| العنوان: | Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies |
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| المؤلفون: | Nichols, H.B, Schoemaker, M.J, Cai, J, Xu, J, Wright, L.B, Brook, M.N, Jones, M.E, Adami, H.-O, Baglietto, L, Bertrand, K.A, Blot, W.J, Boutron-Ruault, M.-C, Dorronsoro, M, Dossus, L, Eliassen, A.H, Giles, G.G, Gram, I.T, Hankinson, S.E, Hoffman-Bolton, J, Kaaks, R, Key, T.J, Kitahara, C.M, Larsson, S.C, Linet, M, Merritt, M.A, Milne, R.L, Pala, V, Palmer, J.R, Peeters, P.H, Riboli, E, Sund, M, Tamimi, R.M, Tjønneland, A, Trichopoulou, A, Ursin, G, Vatten, L, Visvanathan, K, Weiderpass, E, Wolk, A, Zheng, W, Weinberg, C.R, Swerdlow, A.J, Sandler, D.P |
| المصدر: | Annals of Internal Medicine, 170(1) |
| بيانات النشر: | American College of Physicians |
| سنة النشر: | 2019 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | epidermal growth factor receptor 2, maternal age, cancer risk, birth, prospective study, adolescent, pregnancy, follow up, estrogen receptor positive breast cancer, major clinical study, Breast Feeding, Female, breast tumor, parity, Article, estrogen receptor, Parturition, Adult, Breast Neoplasms, nullipara, young adult, risk factor, Proportional Hazards Models, Middle Aged, breast cancer, family history, Genetic Predisposition to Disease, Premenopause, proportional hazards model, Humans |
| الوصف: | Background: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated. Objective: To characterize breast cancer risk in relation to recent childbirth. Design: Pooled analysis of individual-level data from 15 prospective cohort studies. Setting: The international Premenopausal Breast Cancer Collaborative Group. Participants: Women younger than 55 years. Measurements: During 9.6 million person-years of follow-up, 18 826 incident cases of breast cancer were diagnosed. Hazard ratios (HRs) and 95% CIs for breast cancer were calculated using Cox proportional hazards regression. Results: Compared with nulliparous women, parous women had an HR for breast cancer that peaked about 5 years after birth (HR, 1.80 [95% CI, 1.63 to 1.99]) before decreasing to 0.77 (CI, 0.67 to 0.88) after 34 years. The association crossed over from positive to negative about 24 years after birth. The overall pattern was driven by estrogen receptor (ER)-positive breast cancer; no crossover was seen for ER-negative cancer. Increases in breast cancer risk after childbirth were pronounced when combined with a family history of breast cancer and were greater for women who were older at first birth or who had more births. Breastfeeding did not modify overall risk patterns. Limitations: Breast cancer diagnoses during pregnancy were not uniformly distinguishable from early postpartum diagnoses. Data on human epidermal growth factor receptor 2 (HER2) oncogene overexpression were limited. Conclusion: Compared with nulliparous women, parous women have an increased risk for breast cancer for more than 20 years after childbirth. Health care providers should consider recent childbirth a risk factor for breast cancer in young women. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/27pe-5461Test; https://cdr.lib.unc.edu/downloads/6108vp056?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/6108vp056Test |
| DOI: | 10.17615/27pe-5461 |
| الإتاحة: | https://doi.org/10.17615/27pe-5461Test https://cdr.lib.unc.edu/downloads/6108vp056?file=thumbnailTest https://cdr.lib.unc.edu/downloads/6108vp056Test |
| رقم الانضمام: | edsbas.86F0469B |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/27pe-5461 |
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