التفاصيل البيبلوغرافية
| العنوان: |
Maternal Sleep-Disordered Breathing in Pregnancy and Increased Nocturnal Glucose Levels in Women with Gestational Diabetes Mellitus. |
| المؤلفون: |
Newbold, Raphieal, Benedetti, Andrea, Kimoff, R. John, Meltzer, Sara, Garfield, Natasha, Dasgupta, Kaberi, Gagnon, Robert, Lavigne, Lorraine, Olha, Allen, Rey, Evelyne, Pamidi, Sushmita |
| المصدر: |
CHEST; Jan2021, Vol. 159 Issue 1, p356-365, 10p |
| مصطلحات موضوعية: |
GESTATIONAL diabetes, SLEEP apnea syndromes, HIGH-risk pregnancy, GLUCOSE, PREGNANCY, RESEARCH, CROSS-sectional method, RESEARCH methodology, POLYSOMNOGRAPHY, BLOOD sugar, MEDICAL cooperation, EVALUATION research, SEVERITY of illness index, COMPARATIVE studies, RESEARCH funding, QUESTIONNAIRES, BODY mass index |
| مستخلص: |
Background: Women with hyperglycemia during pregnancy are at high risk for adverse perinatal outcomes. Maternal sleep-disordered breathing (SDB) during pregnancy is common and is a risk factor for gestational diabetes mellitus (GDM). However, the relationship between SDB severity and glucose control is unknown.Research Question: Is there an association between SDB severity and glucose levels as assessed by continuous glucose monitoring in GDM?Study Design and Methods: Women with GDM underwent sleep recordings and 72-hour continuous glucose monitoring. Linear mixed models were used to estimate the association of the apnea-hypopnea index (AHI), rapid eye movement (REM)-AHI, and non-REM-AHI with mean glucose levels during nighttime (two periods: 11 pm to 3 am and 3 am to 6 am), daytime (8 am to 9 pm), and 24-hours. Models were adjusted for BMI and antihyperglycemic medications.Results: In 65 participants who were 35 ± 5 (mean ± SD) years of age with BMI of 33 ± 7 kg/m2, 31% were undergoing insulin and/or metformin therapy. A ten-unit increase in AHI was associated with elevated nocturnal glucose levels (11 pm to 3 am: 0.20 mmol/L [95% CI, 0.04-0.40]) with persistent elevations into the morning (8 am: 0.26 mmol/L [95% CI, 0.08-0.4]) when adjusted for BMI and medications. REM-AHI was also associated with higher nocturnal and morning glucose levels, whereas non-REM was not. AHI was not associated with either mean daytime or 24-hour glucose levels.Interpretation: Greater severity of SDB was associated with higher nocturnal and morning glucose levels in women with GDM. [ABSTRACT FROM AUTHOR] |
|
Copyright of CHEST is the property of American College of Chest Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
