Proteomic Approaches to Study SARS-CoV-2 Biology and COVID-19 Pathology
| العنوان: | Proteomic Approaches to Study SARS-CoV-2 Biology and COVID-19 Pathology |
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| المؤلفون: | Ruth Hüttenhain, Paige Haas, Nevan J. Krogan, Monita Muralidharan, Robyn M. Kaake |
| المصدر: | Journal of Proteome Research Journal of proteome research, vol 20, iss 2 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Proteomics, Pathology, Proteome, protein-protein interactions, medicine.disease_cause, Biochemistry, Mass Spectrometry, Pandemic, biomarker discovery, host response, Protein Interaction Maps, Biomarker discovery, Lung, Coronavirus, mass spectrometry, Drug discovery, food and beverages, Biological Sciences, Infectious Diseases, Drug development, Host-Pathogen Interactions, Perspective, Pneumonia & Influenza, Infection, Biotechnology, virus−host interactions, medicine.medical_specialty, Biochemistry & Molecular Biology, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Biology, drug discovery, Vaccine Related, 03 medical and health sciences, Viral Proteins, proteomics, Biodefense, medicine, Humans, Pandemics, Protein Processing, virus-host interactions, 030102 biochemistry & molecular biology, SARS-CoV-2, Prevention, fungi, Post-Translational, COVID-19, Pneumonia, General Chemistry, structural proteomics, Emerging Infectious Diseases, Good Health and Well Being, 030104 developmental biology, Chemical Sciences, Immunization, protein−protein interactions, Protein Processing, Post-Translational |
| الوصف: | The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), was declared a pandemic infection in March 2020. As of December 2020, two COVID-19 vaccines have been authorized for emergency use by the U.S. Food and Drug Administration, but there are no effective drugs to treat COVID-19, and pandemic mitigation efforts like physical distancing have had acute social and economic consequences. In this perspective, we discuss how the proteomic research community can leverage technologies and expertise to address the pandemic by investigating four key areas of study in SARS-CoV-2 biology. Specifically, we discuss how (1) mass spectrometry-based structural techniques can overcome limitations and complement traditional structural approaches to inform the dynamic structure of SARS-CoV-2 proteins, complexes, and virions; (2) virus-host protein-protein interaction mapping can identify the cellular machinery required for SARS-CoV-2 replication; (3) global protein abundance and post-translational modification profiling can characterize signaling pathways that are rewired during infection; and (4) proteomic technologies can aid in biomarker identification, diagnostics, and drug development in order to monitor COVID-19 pathology and investigate treatment strategies. Systems-level high-throughput capabilities of proteomic technologies can yield important insights into SARS-CoV-2 biology that are urgently needed during the pandemic, and more broadly, can inform coronavirus virology and host biology. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1535-3907 1535-3893 |
| DOI: | 10.1021/acs.jproteome.0c00764 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a8c9804dd880a6a1c998d444e34313Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e1a8c9804dd880a6a1c998d444e34313 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15353907 15353893 |
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| DOI: | 10.1021/acs.jproteome.0c00764 |