Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications
| العنوان: | Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications |
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| المؤلفون: | Na Wu, Maochun Hong, Fuyou Li, Feilong Jiang, Lixiang Ye, Pengfei Peng, Yongsheng Liu, Wei Feng |
| المصدر: | ACS Nano. 14:16672-16680 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Chemistry, Upconversion luminescence, General Engineering, General Physics and Astronomy, 02 engineering and technology, Biodegradation, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Fluorescence, Photon upconversion, 0104 chemical sciences, Nanocrystal, In vivo, Biophysics, General Materials Science, 0210 nano-technology, Biological imaging |
| الوصف: | Lanthanide-doped inorganic upconversion nanocrystals (UCNCs) are promising as fluorescent diagnostic and therapeutic agents for in vivo applications ranging from biological imaging to disease theranostics. However, all currently available lanthanide-doped inorganic UCNCs are not biodegradable and thus cannot be harmlessly eliminated from the body of living organism during a reasonable period of time, making their clinical translations nearly impossible. Here, we report a class of red-emitting biodegradable UCNCs based on Yb3+/Er3+-doped inorganic potassium heptafluozirconate (K3ZrF7:Yb/Er) that features a dynamically "soft" crystal lattice containing water-soluble [ZrF7]3- cluster and a K+ cation. The red-emitting K3ZrF7:Yb/Er UCNCs exhibit a pH-dependent biodegradation capability upon exposure to water both in vitro and in vivo, and the rapid biodegradation rate, monitored using the intrinsic red upconversion luminescence, can be tuned particularly in a mild acidic tumor microenvironment (pH ∼5-6). More importantly, the final biodegradation products of K3ZrF7:Yb/Er UCNCs can be excreted from the body of mice in a short period of time with no evidence of toxicity, in stark contrast to the nondegradable β-NaYF4:Yb/Er UCNCs that primarily accumulate in the main organs of mice. These findings described here unambiguously would benefit the future biomedical applications and clinical translations of lanthanide-doped inorganic UCNCs. |
| تدمد: | 1936-086X 1936-0851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::e49a1fcfb07c3e50ac8987f0006a31c4Test https://doi.org/10.1021/acsnano.0c02601Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........e49a1fcfb07c3e50ac8987f0006a31c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1936086X 19360851 |
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