Rapid Assembly of the Polyhydroxylated β-Amino Acid Constituents of Microsclerodermins C, D, and E
| العنوان: | Rapid Assembly of the Polyhydroxylated β-Amino Acid Constituents of Microsclerodermins C, D, and E |
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| المؤلفون: | Bernard Viossat, Pascale Lemoine, David J. Aitken, Sophie Faure, Thomas Hjelmgaard |
| المصدر: | Organic Letters. 10:841-844 |
| بيانات النشر: | American Chemical Society (ACS), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Molecular Structure, Stereochemistry, Organic Chemistry, Sulfonium Compounds, Stereoisomerism, Peptides, Cyclic, Biochemistry, Porifera, Amino acid, Transformation (genetics), chemistry, Animals, Organic chemistry, Imines, Amino Acids, Physical and Theoretical Chemistry |
| الوصف: | A very short and efficient synthesis of protected derivatives of APTO and AETD, the complex polyhydroxylated beta-amino acid residues present in microsclerodermins C, D, and E, is described. The targets are obtained in only five steps, in 23% and 16% overall yields, respectively. The key transformation involves the completely diastereoselective two-carbon homologation of appropriately selected intermediate chiral sulfinimines. |
| تدمد: | 1523-7052 1523-7060 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe67fe55d846798c2bb21be9203cbb7eTest https://doi.org/10.1021/ol702962zTest |
| رقم الانضمام: | edsair.doi.dedup.....fe67fe55d846798c2bb21be9203cbb7e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15237052 15237060 |
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