Specific Lipidome Signatures in Central Nervous System from Methionine-Restricted Mice
| العنوان: | Specific Lipidome Signatures in Central Nervous System from Methionine-Restricted Mice |
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| المؤلفون: | Rosanna Cabré, Manuel Portero-Otin, Reinald Pamplona, Omar Ramírez-Núñez, Corinne M. Spickett, Alba Naudí, Victoria Ayala, Mariona Jové |
| المصدر: | Journal of Proteome Research. 12:2679-2689 |
| بيانات النشر: | American Chemical Society (ACS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Aging, Ceramide, Ubiquinone, Membrane lipids, Longevity, Central nervous system, Biology, Biochemistry, Mice, chemistry.chemical_compound, Methionine, medicine, Animals, Phosphatidylethanolamine, Phosphatidylethanolamines, Brain, Lipid metabolism, General Chemistry, Lipidome, Lipid Metabolism, Adaptation, Physiological, Sphingolipid, Cell biology, Mice, Inbred C57BL, Oxidative Stress, Cholesterol, medicine.anatomical_structure, Liver, Spinal Cord, chemistry, Phosphatidylcholines, Female, Reactive Oxygen Species, Oxidation-Reduction |
| الوصف: | Membrane lipid composition is an important correlate of the rate of aging of animals. Dietary methionine restriction (MetR) increases lifespan in rodents. The underlying mechanisms have not been elucidated but could include changes in tissue lipidomes. In this work, we demonstrate that 80% MetR in mice induces marked changes in the brain, spinal cord, and liver lipidomes. Further, at least 50% of the lipids changed are common in the brain and spinal cord but not in the liver, suggesting a nervous system-specific lipidomic profile of MetR. The differentially expressed lipids includes (a) specific phospholipid species, which could reflect adaptive membrane responses, (b) sphingolipids, which could lead to changes in ceramide signaling pathways, and (c) the physiologically redox-relevant ubiquinone 9, indicating adaptations in phase II antioxidant response metabolism. In addition, specific oxidation products derived from cholesterol, phosphatidylcholine, and phosphatidylethanolamine were significantly decreased in the brain, spinal cord, and liver from MetR mice. These results demonstrate the importance of adaptive responses of membrane lipids leading to increased stress resistance as a major mechanistic contributor to the lowered rate of aging in MetR mice. © 2013 American Chemical Society. |
| تدمد: | 1535-3907 1535-3893 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d6caae770ca787059202f104833562Test https://doi.org/10.1021/pr400064aTest |
| رقم الانضمام: | edsair.doi.dedup.....c0d6caae770ca787059202f104833562 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15353907 15353893 |
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