Chemoenzymatic Process for the Preparation of (S)-7-((tert-Butyldiphenylsilyl)oxy)hept-1-yn-4-ol in a Continuous Packed-Bed Reactor, a Key Intermediate for Eribulin Synthesis
| العنوان: | Chemoenzymatic Process for the Preparation of (S)-7-((tert-Butyldiphenylsilyl)oxy)hept-1-yn-4-ol in a Continuous Packed-Bed Reactor, a Key Intermediate for Eribulin Synthesis |
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| المؤلفون: | Srihari Pabbaraja, Prathama S. Mainkar, Rajesh Nasam, Subhash Ghosh, Thenkrishnan Kumaraguru, Chada Raji Reddy, Samuel L. Ralte, Shalini Basetty, Gangarajula Sudhakar, Srivari Chandrasekhar, Avula Shiva Krishna |
| المصدر: | Organic Process Research & Development. 24:2657-2664 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Packed bed, tert-Butyldiphenylsilyl, chemistry.chemical_compound, chemistry, Biocatalysis, Continuous flow, Organic Chemistry, Enantioselective synthesis, Chemo enzymatic, Physical and Theoretical Chemistry, Medicinal chemistry, Eribulin |
| الوصف: | A practical chemo-enzymatic process has been developed for the preparation of optically pure (S)-7-((tert-butyldiphenylsilyl)oxy)hept-1-yn-4-ol, (S)-4. This was prepared via enantioselective acylat... |
| تدمد: | 1520-586X 1083-6160 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::9408b1e93f5a549722b5341ca6c1b879Test https://doi.org/10.1021/acs.oprd.0c00308Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........9408b1e93f5a549722b5341ca6c1b879 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1520586X 10836160 |
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