Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia
| العنوان: | Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia |
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| المؤلفون: | Ik Jun Moon, Hae Kyeong Yoon, Doyeun Kim, Myung Eun Choi, Seung Hee Han, June Hyun Park, Sun Woo Hong, Hyesoo Cho, Dong-Ki Lee, Chong Hyun Won |
| المصدر: | Molecular Pharmaceutics. 20:128-135 |
| بيانات النشر: | American Chemical Society (ACS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Mice, Disease Models, Animal, Receptors, Androgen, Drug Discovery, Animals, Humans, Pharmaceutical Science, Molecular Medicine, Alopecia, RNA, Messenger, RNA, Small Interfering, Hair Follicle, Hair |
| الوصف: | Asymmetric small interfering RNAs (asiRNAs) that mediate RNA interference have been investigated for therapeutic use in various tissues, including skin tissue. Androgenetic alopecia (AGA) is caused by a combination of genetic factors, resulting in sensitivity to dihydrotestosterone (DHT), which binds to the androgen receptor (AR) to mediate a series of biomolecular changes leading to hair loss. This study aimed to evaluate the therapeutic potential of a cell-penetrating, AR-targeting asiRNA (cp-asiAR) for AGA treatment, which was designed to silence the |
| تدمد: | 1543-8392 1543-8384 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543bcce5d4ddac8b0f12a63ab8ad98a9Test https://doi.org/10.1021/acs.molpharmaceut.2c00510Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....543bcce5d4ddac8b0f12a63ab8ad98a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15438392 15438384 |
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