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المؤلفون: Michael T. Bowen, James R Krycer, Charlotte Fletcher, Lewis J. Martin, Jonathon C. Arnold, Marika Heblinski, Iain S. McGregor, Lyndsey L. Anderson, Elizabeth A. Cairns
المصدر: Journal of Natural Products. 84:1469-1477
مصطلحات موضوعية: In silico, Lactate dehydrogenase A, Pharmaceutical Science, 01 natural sciences, Cofactor, Analytical Chemistry, Cannabichromene, chemistry.chemical_compound, Lactate dehydrogenase, Drug Discovery, Binding site, education, Pharmacology, Virtual screening, education.field_of_study, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Ligand (biochemistry), 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, Biochemistry, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::04f519a2fc8638f2e8daaa9ae7495df1Test
https://doi.org/10.1021/acs.jnatprod.0c01281Test -
2
المؤلفون: Claire Brassington, Giles Hassall, David Whittaker, Richard A. Ward, Alexander L. Breeze, Jonathan Wingfield, Julie A. Tucker, Richard A. Norman, Ryan Greenwood, Martin Vogtherr, Stuart E. Pearson, Kevin Hudson, Jon Winter, Susan E. Critchlow, Gareth M. Davies, Alessandro T. Caputo, Michael Mrosek, Geoffrey A. Holdgate, Louise Goodwin, Jonathan Tart
المصدر: Journal of Medicinal Chemistry. 55:3285-3306
مصطلحات موضوعية: Models, Molecular, Niacinamide, Magnetic Resonance Spectroscopy, Stereochemistry, Lactate dehydrogenase A, Plasma protein binding, Crystallography, X-Ray, Isozyme, Cofactor, Structure-Activity Relationship, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, education, Enzyme Assays, Oxamic Acid, education.field_of_study, L-Lactate Dehydrogenase, Molecular Structure, biology, Chemistry, Nuclear magnetic resonance spectroscopy, Surface Plasmon Resonance, Oxidoreductase inhibitor, Small molecule, Malonates, Rats, Isoenzymes, Biochemistry, Drug Design, biology.protein, Molecular Medicine, Lactate Dehydrogenase 5, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0ccdddf109af173b46a2cede0d6ac4Test
https://doi.org/10.1021/jm201734rTest -
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المؤلفون: Mitchell A. Avery, Amar G. Chittiboyina, Babu L. Tekwani, Anupam Pradhan, Nicholas L. Hammond, Seoung-Ryoung Choi
المصدر: Journal of Medicinal Chemistry. 50:3841-3850
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Swine, Plasmodium falciparum, Malate dehydrogenase, Antimalarials, Structure-Activity Relationship, chemistry.chemical_compound, Malate Dehydrogenase, Lactate dehydrogenase, Drug Discovery, Animals, Structure–activity relationship, chemistry.chemical_classification, Oxamic Acid, Binding Sites, L-Lactate Dehydrogenase, biology, Active site, biology.organism_classification, Recombinant Proteins, In vitro, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Cattle
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec27ebcf2ed29c3310fddca22c737ab8Test
https://doi.org/10.1021/jm070336kTest -
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المؤلفون: M T Makler, Lorraine M. Deck, Brian B. Chamblee, Robert C. Piper, Lucy A. Hunsaker, Jose E. Torres, V M Hernandez, Robert E. Royer, R R Malone, D L Vander Jagt
المصدر: Journal of Medicinal Chemistry. 41:3879-3887
مصطلحات موضوعية: Carboxylic acid, Plasmodium falciparum, chemistry.chemical_compound, Lactate dehydrogenase, Pyruvic Acid, parasitic diseases, Drug Discovery, Animals, Humans, Lactic Acid, Enzyme Inhibitors, chemistry.chemical_classification, L-Lactate Dehydrogenase, biology, NAD, biology.organism_classification, Lactic acid, Dissociation constant, Kinetics, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Pyruvic acid, Oxidation-Reduction, Sesquiterpenes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700d8ffe950b15cc3a138873f4a53d0bTest
https://doi.org/10.1021/jm980334nTest -
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المؤلفون: Peter J. Evans, Tai Ky Vinh, Sook Wah Yee, Mohammed Reza Saberi, Claire Simons, B J Nathan Griffiths
المصدر: Journal of Medicinal Chemistry. 49:1016-1022
مصطلحات موضوعية: Male, Models, Molecular, Pyridines, Stereochemistry, Placenta, Triazole, In Vitro Techniques, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Aromatase, Microsomes, Drug Discovery, Animals, Humans, Structure–activity relationship, Imidazole, Benzofuran, Cytotoxicity, Benzofurans, L-Lactate Dehydrogenase, biology, Aromatase Inhibitors, Chemistry, Imidazoles, Stereoisomerism, Triazoles, Rats, Enzyme inhibitor, Hepatocytes, biology.protein, Microsome, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61785fe57527c8880ef2c218971e519Test
https://doi.org/10.1021/jm0508282Test -
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المؤلفون: Abraham Rubinstein, Tareq Jubeh, Sue Haupt, Yechezkel Barenholz, Sivan Antler
المصدر: Molecular Pharmaceutics. 2:2-11
مصطلحات موضوعية: Male, Xanthine Oxidase, Antioxidant, medicine.medical_treatment, Pharmaceutical Science, Pharmacology, medicine.disease_cause, Antioxidants, Cyclic N-Oxides, Superoxide dismutase, chemistry.chemical_compound, Intestinal mucosa, Cations, Drug Discovery, medicine, Animals, Humans, Cationic liposome, Ferrous Compounds, Intestinal Mucosa, Xanthine oxidase, Hypoxanthine, Liposome, L-Lactate Dehydrogenase, biology, Hydroxyl Radical, Superoxide Dismutase, Chemistry, Adhesiveness, Rats, Inbred Strains, Intestinal epithelium, Rats, Oxidative Stress, Jejunum, Liposomes, Potassium, biology.protein, Feasibility Studies, Molecular Medicine, HT29 Cells, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60927db1757680f15e6778cfc56a7f0Test
https://doi.org/10.1021/mp0499095Test -
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المؤلفون: Zen-saburou Ogita, Yoshiyuki Kimura, Hiromichi Okuda
المصدر: Journal of Natural Products. 60:598-601
مصطلحات موضوعية: Umbilical Veins, Endothelium, Pharmaceutical Science, Pharmacology, Umbilical vein, Cell Line, Analytical Chemistry, chemistry.chemical_compound, Wogonin, Pregnancy, Plasminogen Activator Inhibitor 1, Drug Discovery, medicine, Humans, Trypsin, Flavonoids, Plants, Medicinal, L-Lactate Dehydrogenase, biology, Fibrinolysis, Organic Chemistry, biology.organism_classification, Baicalein, medicine.anatomical_structure, Complementary and alternative medicine, chemistry, Biochemistry, Enzyme inhibitor, Tissue Plasminogen Activator, biology.protein, Molecular Medicine, Scutellaria baicalensis, Oroxylin A, Female, Endothelium, Vascular, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1031cc6168b990bd4392ec1dc8b8ab7dTest
https://doi.org/10.1021/np970035lTest -
8
المصدر: Journal of Medicinal Chemistry. 37:3419-3433
مصطلحات موضوعية: Stereochemistry, Radical polymerization, Acrylic Resins, Hemagglutinins, Viral, Neuraminidase, Hemagglutinin (influenza), Structure-Activity Relationship, chemistry.chemical_compound, Tetramer, Drug Discovery, Polymer chemistry, Animals, Binding Sites, L-Lactate Dehydrogenase, biology, Hemagglutination, Hemagglutination Inhibition Tests, Bromelains, N-Acetylneuraminic Acid, Sialic acid, Monomer, chemistry, Polymerization, Influenza A virus, Acrylamide, Sialic Acids, biology.protein, Molecular Medicine, Chickens, N-Acetylneuraminic acid
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4119726bf7d54a45ffa7f62eb9315aTest
https://doi.org/10.1021/jm00046a027Test -
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المؤلفون: B. R. Baker, Ray R. Bramhall
المصدر: Journal of Medicinal Chemistry. 15:235-237
مصطلحات موضوعية: Alkylation, Carboxylic Acids, Plasma protein binding, Methylation, Malate dehydrogenase, Structure-Activity Relationship, Glutamate Dehydrogenase, Malate Dehydrogenase, Drug Discovery, Structure–activity relationship, Glyceraldehyde 3-phosphate dehydrogenase, chemistry.chemical_classification, L-Lactate Dehydrogenase, biology, Hydrolysis, Glutamate dehydrogenase, Glyceraldehyde-3-Phosphate Dehydrogenases, Leukemia L1210, Enzyme, chemistry, Biochemistry, Quinolines, biology.protein, Molecular Medicine, Oxidoreductases, Acids, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33628b346320c2af52d910dda18dea8Test
https://doi.org/10.1021/jm00273a007Test