نتائج البحث - "Proteasome endopeptidase complex"

1

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Proteasome Endopeptidase Complex, Pyridines, Phenotypic screening, In silico, Antiprotozoal Agents, Drug Evaluation, Preclinical, Protozoan Proteins, Computational biology, Molecular Dynamics Simulation, Scaffold hopping, 01 natural sciences, Article, Cell Line, 03 medical and health sciences, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, East africa, Animals, Humans, 030304 developmental biology, 0303 health sciences, Binding Sites, Drug discovery, Chemistry, medicine.disease, 3. Good health, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Protein Subunits, Visceral leishmaniasis, Proteasome, Solubility, Drug Design, Molecular Medicine, Leishmaniasis, Visceral, Proteasome Inhibitors, Half-Life, Leishmania donovani

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023548cc95d4d9c556b1402e19227eb9Test
http://europepmc.org/articles/PMC8154566Test

2

Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits

المؤلفون: Bogdan I. Florea, Emily S. Weyburne, Bo-Tao Xin, Marissa Janssens, Wolfgang Heinemeyer, Eva M. Huber, Gerjan de Bruin, Michael Groll, Christoph Driessen, Gijsbert A. van der Marel, Alexei F. Kisselev, Christofer Espinal, Yimeng Du, Elmer Maurits, Herman S. Overkleeft

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 62(3), 1626-1642
'Journal of Medicinal Chemistry ', vol: 62, pages: 1626-1642 (2019)

مصطلحات موضوعية: Proteasome Endopeptidase Complex, Saccharomyces cerevisiae Proteins, Structural similarity, Protein subunit, Recombinant Fusion Proteins, Mutagenesis (molecular biology technique), Plasma protein binding, Saccharomyces cerevisiae, Crystallography, X-Ray, Protein Engineering, 01 natural sciences, Article, Small Molecule Libraries, 03 medical and health sciences, Mice, Peptide Library, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Animals, Humans, Peptide library, 030304 developmental biology, 0303 health sciences, Chemistry, Stereoisomerism, Protein engineering, ddc, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Protein Subunits, Proteasome, Structural biology, Biochemistry, Drug Design, Mutation, Molecular Medicine, Oligopeptides, Proteasome Inhibitors, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb18414314eca091bea190815dc2157Test
http://europepmc.org/articles/PMC6378654Test

3

Photoactive bifunctional degraders: precision tools to regulate protein stability

المؤلفون: Kounde, CS, Tate, EW

المساهمون: Engineering and Physical Sciences Research Council

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______1032::90ea0837d508990fc44b674debf14843Test
http://hdl.handle.net/10044/1/84564Test

4

دورية أكاديمية

Thiopeptides Induce Proteasome-Independent Activation of Cellular Mitophagy

المؤلفون: Bird, K.E., Xander, C., Murcia, S., Schmalstig, A.A., Wang, X., Emanuele, M.J., Braunstein, M., Bowers, A.A.

المصدر: ACS Chemical Biology, 15(8)

مصطلحات موضوعية: Peptides, Mitophagy, Eukaryotic Initiation Factor-2, Mice, Sulfhydryl Compounds, Mycobacterium tuberculosis, Phosphorylation, Proteasome Endopeptidase Complex, Anti-Bacterial Agents, Forkhead Box Protein M1, RAW 264.7 Cells, Animals

العلاقة: https://doi.org/10.17615/pjcw-5c61Test; https://cdr.lib.unc.edu/downloads/ff365f949?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/ff365f949Test

الإتاحة: https://doi.org/10.17615/pjcw-5c61Test
https://cdr.lib.unc.edu/downloads/ff365f949?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/ff365f949Test

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5

Polylysine is a Proteostasis Network-Engaging Structural Determinant

المؤلفون: R. Martin Vabulas, Giulia Calloni, Wei-Han Lang

المصدر: Journal of Proteome Research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4c25f6fc258af3721288c35d7c1957Test
http://europepmc.org/articles/PMC5983878Test

6

Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity

المؤلفون: LaMonte, GM, Almaliti, J, Bibo-Verdugo, B, Keller, L, Zou, BY, Yang, J, Antonova-Koch, Y, Orjuela-Sanchez, P, Boyle, CA, Vigil, E, Wang, L, Goldgof, GM, Gerwick, L, O'Donoghue, AJ, Winzeler, EA, Gerwick, WH, Ottilie, S

المصدر: Journal of Medicinal Chemistry
LaMonte, GM; Almaliti, J; Bibo-Verdugo, B; Keller, L; Zou, BY; Yang, J; et al.(2017). Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. JOURNAL OF MEDICINAL CHEMISTRY, 60(15), 6721-6732. doi: 10.1021/acs.jmedchem.7b00671. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0r57k1b0Test

مصطلحات موضوعية: Proteasome Endopeptidase Complex, Plasmodium falciparum, Dipeptides, Hep G2 Cells, Saccharomyces cerevisiae, Article, Artemisinins, Molecular Docking Simulation, Antimalarials, Drug Design, Humans, Oligopeptides, Proteasome Inhibitors, Enzyme Assays

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f8c707eab7509a6569f1586119dd0a99Test
http://europepmc.org/articles/PMC5554889Test

7

دورية أكاديمية

Single Muscle Fiber Proteomics Reveals Distinct Protein Changes in Slow and Fast Fibers during Muscle Atrophy

المؤلفون: Lang F., Khaghani S., Turk C., Wiederstein J. L., Holper S., Piller T., Nogara L., Blaauw B., Gunther S., Muller S., Braun T., Kruger M.

المساهمون: Lang, F., Khaghani, S., Turk, C., Wiederstein, J. L., Holper, S., Piller, T., Nogara, L., Blaauw, B., Gunther, S., Muller, S., Braun, T., Kruger, M.

مصطلحات موضوعية: calcium signaling, denervation, muscle atrophy, single muscle fiber, Animal, Mice, Inbred C57BL, Mitochondrial Protein, Muscle Contraction, Muscle Denervation, Muscle Fibers, Fast-Twitch, Skeletal, Slow-Twitch, Muscle Protein, Muscle, Muscular Atrophy, Myosin Heavy Chain, Proteasome Endopeptidase Complex, Proteome, Proteomics

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30142977; info:eu-repo/semantics/altIdentifier/wos/WOS:000447118300001; volume:17; issue:10; firstpage:3333; lastpage:3347; numberofpages:15; journal:JOURNAL OF PROTEOME RESEARCH; http://hdl.handle.net/11577/3321709Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85053404671; http://pubs.acs.org/journal/jprobsTest

الإتاحة: https://doi.org/10.1021/acs.jproteome.8b00093Test
http://hdl.handle.net/11577/3321709Test
http://pubs.acs.org/journal/jprobsTest

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