التفاصيل البيبلوغرافية
| العنوان: |
IL-33 Is a Negative Regulator of Vaccine-Induced Antigen-Specific Cellular Immunity. |
| المؤلفون: |
O'Grady, Katie1, Hearnden, Claire C. H.1, Bento, Dulce1, Oleszycka, Ewa1, Andersen, Peter2, Muñoz-Wolf, Natalia1, Lavelle, Ed C.1,3,4 lavellee@tcd.ie |
| المصدر: |
Journal of Immunology. 2/15/2019, Vol. 202 Issue 4, p1145-1152. 8p. |
| مستخلص: |
The cytokine IL-33 is a well-established inducer of Th2 responses. However, roles for IL-33 in promoting CD8, Th1, and T regulatory cell responses have also emerged. In this study, the role of IL-33 as a regulator of particulate vaccine adjuvantinduced Ag-specific cellular immunity was investigated. We found that polymeric nanoparticles surpassed alum in their ability to enhance Ag-specific CD8 and Th1 responses. IL-33 was a potent negative regulator of both CD8+ T cell and Th1 responses following i.m. vaccination with Ag and nanoparticles, whereas the cytokine was required for the nanoparticle enhancement in Ag-specific IL-10. In contrast to the effect on cellular immunity, Ab responses were comparable between vaccinated wild-type and IL-33-deficient mice. IL-33 did not compromise alum-induced adaptive cellular immunity after i.m. vaccination. These data suggest that IL-33 attenuates the induction of cellular immune responses by nanoparticulate adjuvants and should be considered in the rational design of vaccines targeting enhanced CD8 and Th1 responses. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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