التفاصيل البيبلوغرافية
| العنوان: |
Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients. |
| المؤلفون: |
Hutchinson, James A.1,2 james.hutchinson@klinik.uni-regensburg.de, Riquelme, Paloma1,2, Sawitzki, Birgit2,3, Tomiuk, Stefan2,4, Miqueu, Patrick2,5, Zuhayra, Maaz6, Oberg, Hans H.7, Pascher, Andreas8, Lützen, Ulf6, Janßen, Uwe2,4, Broichhausen, Christiane1, Renders, Lutz9, Thaiss, Friedrich10, Scheuermann, Ernst11, Henze, Eberhard6, Volk, Hans-Dieter2,3, Chatenoud, Lucienne2,12, Lechler, Robert I.2,13, Wood, Kathryn J.2,14, Kabelitz, Dieter7 |
| المصدر: |
Journal of Immunology. 9/1/2011, Vol. 187 Issue 5, p2072-2078. 7p. |
| مصطلحات موضوعية: |
*MACROPHAGES, *GENE expression, *BONE marrow, *MESSENGER RNA, *RNA |
| مستخلص: |
Regulatory macrophages (M regs) were administered to two living-donor renal transplant recipients. Both patients were minimized to low-dose tacrolimus mono- therapy within 24 wk of transplantation and subse- quently maintained excellent graft function. After central venous administration, most M regs remained viable and were seen to traffic from the pulmonary vas culature via the blood to liver, spleen, and bone marrow. By 1 y posrtransplantation, both patients displayed pat- terns of peripheral blood gene expression converging upon the IOT-RISET signature. Furthermore, both patients maintained levels of peripheral blood FOXP3 and TOAG-1 mRNA expression within the range consistent with nonrejection. It is concluded that M regs warrant further study as a potential immune-conditioning ther apy for use in solid-organ transplantation. The results of this work ate being used to inform the design of The ONE Study, a multinational clinical trial of immunomodulatory cell therapy in renal transplantation. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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