NMDA Receptor Losses in Putamen from Patients with Huntington's Disease
| العنوان: | NMDA Receptor Losses in Putamen from Patients with Huntington's Disease |
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| المؤلفون: | Constance J. D'Amato, John B. Penney, Ira Shoulson, Zane R. Hollingsworth, J. T. Greenamyre, Anne B. Young, Roger L. Albin |
| المصدر: | Science. 241:981-983 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 1988. |
| سنة النشر: | 1988 |
| مصطلحات موضوعية: | medicine.medical_specialty, Receptors, Drug, AMPA receptor, Receptors, N-Methyl-D-Aspartate, Huntington's disease, Internal medicine, medicine, Humans, Neurotoxin, Receptors, AMPA, Receptor, Phencyclidine, Cerebral Cortex, Multidisciplinary, Chemistry, Putamen, Receptors, GABA-A, medicine.disease, Receptors, Muscarinic, Receptors, Neurotransmitter, Huntington Disease, Endocrinology, medicine.anatomical_structure, nervous system, Cerebral cortex, NMDA receptor, Receptors, Phencyclidine, medicine.drug |
| الوصف: | N-Methyl-D-aspartate (NMDA), phencyclidine (PCP), and quisqualate receptor binding were compared to benzodiazepine, gamma-aminobutyric acid (GABA), and muscarinic cholinergic receptor binding in the putamen and cerebral cortex of individuals with Huntington's disease (HD). NMDA receptor binding was reduced by 93 percent in putamen from HD brains compared to binding in normal brains. Quisqualate and PCP receptor binding were reduced by 67 percent, and the binding to other receptors was reduced by 55 percent or less. Binding to these receptors in the cerebral cortex was unchanged in HD brains. The results support the hypothesis that NMDA receptor-mediated neurotoxicity plays a role in the pathophysiology of Huntington's disease. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4e124bcef2a900048ce91f014de22dTest https://doi.org/10.1126/science.2841762Test |
| رقم الانضمام: | edsair.doi.dedup.....dc4e124bcef2a900048ce91f014de22d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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