Immune Response in Mice that Lack the Interferon-γ Receptor
| العنوان: | Immune Response in Mice that Lack the Interferon-γ Receptor |
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| المؤلفون: | Ryutaro Kamijo, Horst Bluethmann, Michel Aguet, Jan Vilcek, Rolf M. Zinkernagel, Silvio Hemmi, Alana Althage, Wiljan Hendriks, Sui Huang |
| المصدر: | Science. 259:1742-1745 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Multidisciplinary, biology, T helper cell, Major histocompatibility complex, Immune system, medicine.anatomical_structure, Antigen, Interferon-gamma receptor, Immunology, biology.protein, medicine, Cytotoxic T cell, Interferon gamma, Antibody, medicine.drug |
| الوصف: | Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance, they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::3071841ea12240719d6f874d08683727Test https://doi.org/10.1126/science.8456301Test |
| رقم الانضمام: | edsair.doi...........3071841ea12240719d6f874d08683727 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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