التفاصيل البيبلوغرافية
| العنوان: |
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis |
| المؤلفون: |
Brewer, R. Camille, Lanz, Tobias V., Hale, Caryn R., Sepich-Poore, Gregory D., Martino, Cameron, Swafford, Austin D., Carroll, Thomas S., Kongpachith, Sarah, Blum, Lisa K., Elliott, Serra E., Blachere, Nathalie E., Parveen, Salina, Fak, John, Yao, Vicky, Troyanskaya, Olga, Frank, Mayu O., Bloom, Michelle S., Jahanbani, Shaghayegh, Gomez, Alejandro M., Iyer, Radhika, Ramadoss, Nitya S., Sharpe, Orr, Chandrasekaran, Sangeetha, Kelmenson, Lindsay B., Wang, Qian, Wong, Heidi, Torres, Holly L., Wiesen, Mark, Graves, Dana T., Deane, Kevin D., Holers, V. Michael, Knight, Rob, Darnell, Robert B., Robinson, William H., Orange, Dana E. |
| المصدر: |
Science Translational Medicine ; volume 15, issue 684 ; ISSN 1946-6234 1946-6242 |
| بيانات النشر: |
American Association for the Advancement of Science (AAAS) |
| سنة النشر: |
2023 |
| الوصف: |
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis of human and bacterial transcriptomics in longitudinal blood samples from RA patients. We found that patients with RA and periodontal disease experienced repeated oral bacteremias associated with transcriptional signatures of ISG15 + HLADR hi and CD48 high S100A2 pos monocytes, recently identified in inflamed RA synovia and blood of those with RA flares. The oral bacteria observed transiently in blood were broadly citrullinated in the mouth, and their in situ citrullinated epitopes were targeted by extensively somatically hypermutated ACPAs encoded by RA blood plasmablasts. Together, these results suggest that (i) periodontal disease results in repeated breaches of the oral mucosa that release citrullinated oral bacteria into circulation, which (ii) activate inflammatory monocyte subsets that are observed in inflamed RA synovia and blood of RA patients with flares and (iii) activate ACPA B cells, thereby promoting affinity maturation and epitope spreading to citrullinated human antigens. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1126/scitranslmed.abq8476 |
| الإتاحة: |
https://doi.org/10.1126/scitranslmed.abq8476Test |
| رقم الانضمام: |
edsbas.40DAE740 |
| قاعدة البيانات: |
BASE |
