التفاصيل البيبلوغرافية
| العنوان: |
CTLA-4 Control over Foxp3 + Regulatory T Cell Function |
| المؤلفون: |
Wing, Kajsa, Onishi, Yasushi, Prieto-Martin, Paz, Yamaguchi, Tomoyuki, Miyara, Makoto, Fehervari, Zoltan, Nomura, Takashi, Sakaguchi, Shimon |
| المصدر: |
Science ; volume 322, issue 5899, page 271-275 ; ISSN 0036-8075 1095-9203 |
| بيانات النشر: |
American Association for the Advancement of Science (AAAS) |
| سنة النشر: |
2008 |
| الوصف: |
Naturally occurring Foxp3 + CD4 + regulatory T cells (Tregs) are essential for maintaining immunological self-tolerance and immune homeostasis. Here, we show that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell–mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice, and it also produces potent tumor immunity. Treg-specific CTLA-4 deficiency impairs in vivo and in vitro suppressive function of Tregs—in particular, Treg-mediated down-regulation of CD80 and CD86 expression on dendritic cells. Thus, natural Tregs may critically require CTLA-4 to suppress immune responses by affecting the potency of antigen-presenting cells to activate other T cells. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1126/science.1160062 |
| الإتاحة: |
https://doi.org/10.1126/science.1160062Test |
| رقم الانضمام: |
edsbas.A081AD39 |
| قاعدة البيانات: |
BASE |
