Lupus: subdivide in order to conquer?
| العنوان: | Lupus: subdivide in order to conquer? |
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| المؤلفون: | Paula A. Kiberstis |
| المصدر: | Science. 352:1072-1073 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Autoimmune disease, Multidisciplinary, Systemic lupus erythematosus, business.industry, Cell, Autoantibody, medicine.disease, Molecular heterogeneity, Patient care, Disease activity, medicine.anatomical_structure, Immunology, medicine, Kidney inflammation, business |
| الوصف: | Autoimmune Disease For some diseases such as cancer, doctors routinely use molecular profiling to match patients to the most effective drugs, leading to improved patient care. With this goal in mind, Banchereau et al. explore the molecular heterogeneity of systemic lupus erythematosus, an autoimmune disease in which patients produce autoantibodies to nucleic acids. Through longitudinal profiling of blood samples from 158 children with lupus, they found a transcriptional signature in plasmablasts (a type of antibody-secreting cell) that strongly correlates with disease activity. Notably, a rise in neutrophil transcripts marked the onset of kidney inflammation. Overall, this approach revealed that lupus patients fall into seven subgroups, who conceivably would show different responses to treatment. Cell 165 , 551 (2016). |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::86702321e82128c01d1b5248b140a847Test https://doi.org/10.1126/science.352.6289.1072-cTest |
| رقم الانضمام: | edsair.doi...........86702321e82128c01d1b5248b140a847 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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