المؤلفون: Ianevski, Aleksandr, Lahtela, Jenni, Javarappa, Komal K., Sergeev, Philipp, Ghimire, Bishwa R., Gautam, Prson, Vähä-Koskela, Markus, Turunen, Laura, Linnavirta, Nora, Kuusanmaki, Heikki, Kontro, Mika, Porkka, Kimmo, Heckman, Caroline A., Mattila, Pirkko, Wennerberg, Krister, Giri, Anil K., Aittokallio, Tero

المساهمون: Computational Systems Medicine, Institute for Molecular Medicine Finland, Medicum, Department of Medicine, HUS Comprehensive Cancer Center, Biosciences, Krister Wennerberg / Principal Investigator, Helsinki Institute for Information Technology, Tero Aittokallio / Principal Investigator, Bioinformatics

مصطلحات موضوعية: 113 Computer and information sciences

وصف الملف: application/pdf

العلاقة: We are grateful to the patients who have donated samples to the study. We thank the FIMM High Throughput Biomedicine and Single-Cell Analytics units supported by HiLIFE and Biocenter Finland for technical support, D. Malani (FIMM) for information about the patient samples, O. Kallioniemi (Science for Life Laboratory, Sweden) for financial support for the molecular and compound profiling, and S. Potluri (Senior Principal Scientist at Pfizer Rinat Laboratories, SF, USA) for the scRNA-seq data generation. The work was partially funded by the Academy of Finland (grants 310507, 313267, 326238, and 344698 to T.A.); iCAN Digital Precision Cancer Medicine Flagship (grant 1320185 to T.A. and C.A.H.); Cancer Society of Finland (T.A., K.W., and C.A.H.); Sigrid Juselius Foundation (K.P., T.A., and K.W.); Helse Sor-Ost (grant 2020026 to T.A.); Helsinki University Hospital and Business Finland joint project eCare4Me/Block 2 (BF grant 6767/31/2018 to K.P.); Novo Nordisk Foundation (grant NNF17CC0027852 to K.W.); and Finnish Medical Foundation, Finnish Cancer Institute (M.K.).; Ianevski , A , Lahtela , J , Javarappa , K K , Sergeev , P , Ghimire , B R , Gautam , P , Vähä-Koskela , M , Turunen , L , Linnavirta , N , Kuusanmaki , H , Kontro , M , Porkka , K , Heckman , C A , Mattila , P , Wennerberg , K , Giri , A K & Aittokallio , T 2021 , ' Patient-tailored design for selective co-inhibition of leukemic cell subpopulations ' , Science Advances , vol. 7 , no. 8 , 4038 . https://doi.org/10.1126/sciadv.abe4038Test; ORCID: /0000-0002-0886-9769/work/90527779; ORCID: /0000-0001-7750-167X/work/90527977; ORCID: /0000-0002-7780-482X/work/90528399; ORCID: /0000-0003-4112-5902/work/90530129; ORCID: /0000-0002-0234-1568/work/90530645; ORCID: /0000-0001-6353-0664/work/133998499; ORCID: /0000-0001-5076-8366/work/152343060; ORCID: /0000-0003-0274-4794/work/155648897; http://hdl.handle.net/10138/327856Test; 110fda10-6946-406a-bd71-f4caff020446; 000620146100029

الإتاحة: http://hdl.handle.net/10138/327856Test

المؤلفون: Ianevski, Aleksandr, Lahtela, Jenni, Javarappa, Komal K., Sergeev, Philipp, Ghimire, Bishwa R., Gautam, Prson, Vähä-Koskela, Markus, Turunen, Laura, Linnavirta, Nora, Kuusanmäki, Heikki, Kontro, Mika, Porkka, Kimmo, Heckman, Caroline A., Mattila, Pirkko, Wennerberg, Krister, Giri, Anil K., Aittokallio, Tero

المساهمون: Helse Sør-Øst RHF, Novo Nordisk Foundation Center for Basic Metabolic Research, Business Finland, Academy of Finland, Finnish Medical Foundation, Sigrid Jusélius Foundation, Cancer Society of Finland

المصدر: Science Advances ; volume 7, issue 8 ; ISSN 2375-2548

الإتاحة: https://doi.org/10.1126/sciadv.abe4038Test