Molecular Evolution of the SARS Coronavirus During the Course of the SARS Epidemic in China
| العنوان: | Molecular Evolution of the SARS Coronavirus During the Course of the SARS Epidemic in China |
|---|---|
| المؤلفون: | Xiangyin Kong, Hua Tang, Xin Zhang, Xin Wei Wu, Zhihong Hu, Stephen S.C. Chim, Rossa W.K. Chiu, Yang Zhong, Bo Wei Gu, Huajun Zheng, Shuang Xi Ren, Jin Lin Hou, Kui Zheng, Rui Heng Xu, Chung-I Wu, Qi Liu, Guoping Zhao, You Gang Miao, Guo Wen Peng, Gang Fu, Ling Fang, Mei He, De Wen Yu, Zong Ming Guo, Huan Ying Zheng, Pei Hao, Zhu Chen, Bo Fei Wang, Jin Yan Lin, Xiao Ning Wang, Sai Juan Chen, Jiahai Lu, Jun Xu, Jun Min, Wei Zhong He, Wen Jia Liang, Xin Ge Yan, Yixue Li, Zhuo Yue Wan, Hui Li, Zhan Hui Wang, Guo Wei Zhang, Xiang Lin Zhang, Xiang Jun Zhou, Yu K. Tong, Shengyue Wang, Shuyi Zhang, Jian Feng He, Y.M. Dennis Lo, Huai Dong Song, Ji Cheng Huang, Paul K.S. Chan, John S. Tam |
| المصدر: | Science. 303:1666-1669 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | China, Genotype, Coronavirus M Proteins, Carnivora, Molecular Sequence Data, Genome, Viral, Biology, Severe Acute Respiratory Syndrome, Disease Outbreaks, Evolution, Molecular, Viral Matrix Proteins, Open Reading Frames, Viral Envelope Proteins, Molecular evolution, Animals, Cluster Analysis, Humans, Point Mutation, Selection, Genetic, Phylogeny, Sequence Deletion, Genetics, Membrane Glycoproteins, Multidisciplinary, Base Sequence, Adaptation, Physiological, Virology, Coronavirus, Amino Acid Substitution, Severe acute respiratory syndrome-related coronavirus, Mutation, Spike Glycoprotein, Coronavirus, Nucleic Acid Conformation, RNA, Viral, Severe acute respiratory syndrome coronavirus |
| الوصف: | Sixty-one SARS coronavirus genomic sequences derived from the early, middle, and late phases of the severe acute respiratory syndrome (SARS) epidemic were analyzed together with two viral sequences from palm civets. Genotypes characteristic of each phase were discovered, and the earliest genotypes were similar to the animal SARS-like coronaviruses. Major deletions were observed in the Orf8 region of the genome, both at the start and the end of the epidemic. The neutral mutation rate of the viral genome was constant but the amino acid substitution rate of the coding sequences slowed during the course of the epidemic. The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250413d2c855d939138596b407c3536bTest https://doi.org/10.1126/science.1092002Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....250413d2c855d939138596b407c3536b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
|---|