التفاصيل البيبلوغرافية
| العنوان: |
Effect of Serotonergic Afferents on Quantal Release at Central Inhibitory Synapses |
| المؤلفون: |
Mintz, Isabelle, Gotow, Takahiro, Triller, Antoine, Korn, Henri |
| المصدر: |
Science ; volume 245, issue 4914, page 190-192 ; ISSN 0036-8075 1095-9203 |
| بيانات النشر: |
American Association for the Advancement of Science (AAAS) |
| سنة النشر: |
1989 |
| الوصف: |
Although most examples of modulation of synaptic transmission have been obtained from excitatory rather than from inhibitory connections, serotonin (5HT) is now shown to cause a presynaptic facilitation of release of the inhibitory neurotransmitter glycine. Brief local injections of this amine, or application of a 5HT uptake blocker, produce a long-lasting enhancement of both spontaneous and evoked inhibitory currents in the teleost Mauthner cell. Quantal analysis showed that the probability of release is increased. Focal recording indicated that 5HT acts directly on the inhibitory terminals, possibly reducing potassium conductances. Double staining with specific antibodies demonstrated a morphological substrate for this effect. Nerve endings that contain 5HT contact inhibitory terminals directly apposed to postsynaptic glycine receptors. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1126/science.2749257 |
| الإتاحة: |
https://doi.org/10.1126/science.2749257Test |
| رقم الانضمام: |
edsbas.183B3B71 |
| قاعدة البيانات: |
BASE |
